832-41-7

Upstream product

• 627-42-9 2-chloroethyl methyl ether 
• 70-55-3 toluene-4-sulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 109-85-3 2-methoxyethylamine 
• 107-25-5 methoxyethene 
• 106-45-6 para-thiocresol 

Downstream Products

• 17900-53-7 2-methyl-1-(4-methylbenzenesulfonyl)-1H-pyrrole 
• 14627-24-8 3-tosyl-1,3-oxazolidine 
• 837-10-5 N-(2-methoxy-ethyl)-N-nitroso-toluene-4-sulfonamide 

Relevant academic research and scientific papers

Electrochemical C?H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium

The construction of C?N bonds by free radical reactions represents a powerful synthetic approach for direct C?H amidations of arenes or heteroarenes. Developing efficient and more environmentally friendly synthetic methods for C?H amidation reactions remains highly desirable. Herein, metal-free electrochemical oxidative dehydrogenative C?H amidations of heteroarenes with N-alkylsulfonamides have been accomplished. The catalyst- and chemical-oxidant-free C?H amidation features an ample scope and employs electricity as the green and sole oxidant. A variety of heteroarenes, including indoles, pyrroles, benzofuran and benzothiophene, thereby underwent this C(sp2)?H nitrogenation. Cyclic voltammetry studies and control experiments provided evidence for nitrogen-centered radicals being directly generated under metal-free electrocatalysis.

Merging Photochemistry with Electrochemistry: Functional-Group Tolerant Electrochemical Amination of C(sp3)?H Bonds

Direct amination of C(sp3)?H bonds is of broad interest in the realm of C?H functionalization because of the prevalence of nitrogen heterocycles and amines in pharmaceuticals and natural products. Reported here is a combined electrochemical/pho

Metal-free I2O5-mediated direct construction of sulfonamides from thiols and amines

A simple and convenient method has been developed for the construction of sulfonamides via I2O5-mediated sulfonylation of amines with arylthiols. The present protocol provides an attractive approach to sulfonamides in moderate to good yields from readily accessible and easy to handle starting materials under mild and metal-free conditions.

Preparation method of sulfonamides compound

The invention discloses a reparation method of a sulfonamides compound. The preparation method includes: using thiophenol and amine which are simple and easy to get as raw materials; enabling the raw materials to be in direct oxidation coupling reaction under mediation of safe and stable iodine pentoxide to prepare sulfonamide. The preparation method has the advantages that reaction conditions are mild (60 DEG C), the raw materials are simple and easy to get and low in price, reaction environment is friendly, a substrate is wide in application range, and metal catalysts and harsh reaction conditions like low or high temperature and zero water and zero oxygen are not needed, so that metal pollution related to common synthesis methods is avoided; the preparation method further has the advantages of simple, convenient and safe operation, stable process condition and easiness in product purification and is suitable for large-scale production.

ALUMINA CATALYZED TRANSFORMATION OF O-(3-OXOBUTYL) URETHANES

The alumina-catalyzed transformations of urethane to a secundary amine and a sulfonyl urethane to a sulfonamide are described.Alumina is also shown to catalyze the conjugate addition of p-toluenesulfonamide to methyl vinyl ketone.