83207-58-3

Usage

Uses

Used in Pharmaceutical Industry:
Astragaloside A is used as a cardioprotective agent for protecting cardiomyocytes from apoptosis caused by ischemia/reperfusion. It also serves as an anti-inflammatory agent by inhibiting inflammation signaled through TNF-α.
Used in Regenerative Medicine:
Astragaloside A is used as a stimulant for angiogenesis, promoting the formation of new blood vessels, which is crucial for tissue repair and regeneration.
Used in Neuroregeneration:
Astragaloside A is used as a neuroregenerative agent for promoting the differentiation of neural stem cells and increasing neuroregeneration, which can be beneficial for the treatment of neurodegenerative diseases and injuries.
Used in Immune System Support:
Although not explicitly mentioned in the provided materials, given its role in traditional Chinese medicine and its protective effects on the immune system, Astragaloside A could potentially be used as an immune system support agent to enhance the body's natural defenses against diseases and infections.

benefits

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.

Health effects

As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

Pharmaceutical Applications

Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

InChI:InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27?,28-,29+,30?,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1

Upstream product

• 223924-10-5 16-O-acetyl-20R,24S-epoxycycloartan-3γb,6α,16β,25-tetraol 3-O-β-D-xylopyranoside 6-O-β-D-glucopyranoside 
• 84680-75-1 cyclosiversioside B 
• 84676-89-1 cyclosiversioside D 
• 133-89-1 UDP-glucose 
• 86541-83-5 cyclosieversigenin 3-O-β-D-xylopyranoside 
• 84680-75-1 (3β,6α,16β,20R,24S)-3-[(2,3-di-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside 
• 84676-89-1 (3b,6a,16b,20R,24S)-3-((2-O-acetyl-beta-D-xylopyranosyl)oxy)-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside 
• 84687-47-8 acetylastragaloside I 
• 84687-45-6 astragaloside VI 
• 84687-46-7 (3β,6α,16β,20R,24S)-20,24-epoxy-16-hydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostane-6,25-diyl bis[β-D-glucopyranoside] 
• 84676-88-0 isoastragaloside I 
• 86764-11-6 isoastragalosides II 
• 88192-83-0 cyclosiversioside H 

Downstream Products

• 78574-94-4 cyclosieversigenin 
• 83207-61-8 cyclosieversigenin 6-O-β-D-glucopyranoside 
• 83207-60-7 cyclosieversigenin 3-O-β-D-xylopyranoside 
• 84605-18-5 cycloastragenol 
• 86541-83-5 cyclosieversigenin 3-O-β-D-xylopyranoside 
• 86764-12-7 cyclosieversigenin 6-O-β-D-glucopyranoside 
• 86541-79-9 astragenol 

Relevant academic research and scientific papers

TRITERPENE GLYCOSIDES OF Astragalus AND THEIR GENINS. XV. CYCLOSIVERSIOSIDES B AND D FROM Astragalus basineri

Two new glycosides have been isolated from the roots of the plant Astragalus basineri Trautv. - cyclosiversiosides B and D.It has been shown that cyclosiversioside B is cyclosiversigenin 3-O-(2',3'-di-O-acetyl-β-D-xylopyranoside)-6-O-β-D-glucopyranoside.Cyclosiversioside D is cyclosiversigenin 3-O-(2'-O-acetyl-β-D'-xylopyranoside)-6-O-β-D-glucopyranoside.

Functional Characterization and Protein Engineering of a Triterpene 3-/6-/2′-O-Glycosyltransferase Reveal a Conserved Residue Critical for the Regiospecificity

Engineering the function of triterpene glucosyltransferases (GTs) is challenging due to the large size of the sugar acceptors. In this work, we identified a multifunctional glycosyltransferase AmGT8 catalyzing triterpene 3-/6-/2′-O-glycosylation from the medicinal plant Astragalus membranaceus. To engineer its regiospecificity, a small mutant library was built based on semi-rational design. Variants A394F, A394D, and T131V were found to catalyze specific 6-O, 3-O, and 2′-O glycosylation, respectively. The origin of regioselectivity of AmGT8 and its A394F variant was studied by molecular dynamics and hydrogen deuterium exchange mass spectrometry. Residue 394 is highly conserved as A/G and is critical for the regiospecificity of the C- and O-GTs TcCGT1 and GuGT10/14. Finally, astragalosides III and IV were synthesized by mutants A394F, T131V and P192E. This work reports biocatalysts for saponin synthesis and gives new insights into protein engineering of regioselectivity in plant GTs.

Synthetic Access Toward Cycloastragenol Glycosides

The first efficient synthetic approach toward four types of the cycloartane glycosides, the cycloastragenol 25-O; 3-O; 3,6-O-bis; and 3,25-O-bisglycoside, have been established, which featured the PPY-mediated, concentration-controlled acetylation and Au(I)-catalyzed Yu glycosylation. Through the synthetic investigation, the reactivity sequence of the four OHs in cycloastragenol was fixed for the first time and a detour strategy for the highly efficient removal of bulky pivaloyl protecting groups was discovered.

Triterpene glycosides from Tragacantha stipulosa and their genins. Structure of cyclostipuloside E

The known compound trojanoside A(1) and a new cycloartane glycoside cyclostipuloside E (2) were isolated from the aerial parts of Tragacantha stipulosa Boriss. The structure of cyclostipuloside E was proposed as 24R-cycloartan-3β,6α,16β,24,25-pentaol6,16,25-tri-O-β-D- glucopyranoside3-O-β-D-xylopyranoside based on physicochemical data and chemical transformations.

TRITERPENE GLYCOSIDES OF Astragalus AND THEIR GENINS. XIII. THE STRUCTURE OF CYCLOSIVERSIOSIDE H - A TRIGLYCERIDE FROM Astragalus sieversianus

A new triglycoside of the cycloartane series has been isolated from the roots of Astragalus sieversianus Pall.; it is cyclosieversigenin 6-O-β-D-glucopyranoside 3-O-2)-β-D-xylopyranoside>.