832103-01-2

Basic information

• Product Name: 5-amino-N,N-dimethyl-1-benzothiophene-2-carboxamide
• Synonyms: 5-amino-N,N-dimethyl-1-benzothiophene-2-carboxamide;benzo[b]thiophene-2-carboxamide, 5-amino-N,N-dimethyl-;5-amino-N,N-dimethyl-1-benzothiophene-2-carboxamide(SALTDATA: FREE);5-amino-N,N-dimethyl-2-benzothiophenecarboxamide;5-amino-N,N-dimethyl-benzothiophene-2-carboxamide;5-amino-N,N-dimethyl-benzo[b]thiophene-2-carboxamide
• CAS NO: 832103-01-2
• Molecular Formula: C₁₁H₁₂N₂OS
• Molecular Weight: 220.295
• Mol File: 832103-01-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 442.944°C at 760 mmHg
• Flash Point: 221.685°C
• Appearance: /
• Density: 1.291g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.689
• CAS DataBase Reference: 5-amino-N,N-dimethyl-1-benzothiophene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-N,N-dimethyl-1-benzothiophene-2-carboxamide(832103-01-2)
• EPA Substance Registry System: 5-amino-N,N-dimethyl-1-benzothiophene-2-carboxamide(832103-01-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 832103-01-2(Hazardous Substances Data)

Usage

General Description

5-amino-N,N-dimethyl-1-benzothiophene-2-carboxamide is a chemical compound with the molecular formula C12H14N2OS. It is a benzothiophene derivative and belongs to the class of carboxamides. 5-amino-N,N-dimethyl-1-benzothiophene-2-carboxamide contains an amino group, two methyl groups, and a carboxamide group attached to the benzothiophene ring. It may have potential applications in pharmaceuticals, agrochemicals, and other industries due to its unique structure and properties. However, further research and studies are needed to fully understand and exploit its potential uses.

InChI:InChI=1/C11H12N2OS/c1-13(2)11(14)10-6-7-5-8(12)3-4-9(7)15-10/h3-6H,12H2,1-2H3

Upstream product

• 20532-45-0 N,N-dimethyl-5-nitro-1-benzothiophene-2-carboxamide 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 6345-55-7 5-nitrobenzo[b]thiophene-2-carboxylic acid 
• 20699-86-9 methyl 5-nitrobenzo[b]thiophene-2-carboxylate 

Relevant articles and documents

6-(4-Chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist

Genetic manipulation studies in mice at both the MCH receptor 1 (MCHR1) as well as the MCH peptide levels have implicated MCHR1 as a key player in energy homeostasis. The phenotype exhibited by these studies, that is, increased metabolic rate, resistance to high fat diet, and subsequent weight loss, has spurred considerable efforts to develop antagonists of MCHR1. In continuation of efforts directed toward this goal, the present work capitalizes on the putative binding mode of an MCH antagonist, resulting in the identification of several novel chemotypes that are potent and selective MCHR1 antagonists. In addition, the favorable pharmacokinetics of representative examples has allowed for the evaluation of an MCHR1 antagonist in a high fat diet-induced obese rodent model of obesity. The tolerability of the right-hand side of the template for diverse chemotypes accompanied by favorable effects on weight loss enhances the attractiveness of this template in the pursuit toward development of effective anti-obesity agents.