83237-27-8

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Hydroxyethyl)cyclobutanol is used as a building block for the synthesis of various pharmaceuticals due to its unique structure and properties. It serves as a valuable intermediate in the development of new chemical entities for medicinal applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2-Hydroxyethyl)cyclobutanol is utilized as a building block in the synthesis of agrochemicals, contributing to the development of innovative products for agricultural use.
Used in Fragrance and Flavor Industry:
1-(2-Hydroxyethyl)cyclobutanol is used as a component in the production of fragrances and flavors because of its pleasant odor, enhancing the sensory qualities of various consumer products.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1191-95-3 cyclobutanone 
• 73039-83-5 1-oxa-spiro[2.3]hexane-2-carboxylic acid ethyl ester 
• 67-56-1 methanol 
• 73637-29-3 5,7-dioxaspiro<3.5>nonane 

Downstream Products

• 1369331-42-9 4-oxa-5-phenylspiro[3.4]octane 
• 1369331-33-8 C₂₀H₂₃ClO₂S 
• 955930-07-1 2-(1-hydroxycyclobutyl)ethyl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

A new approach to the synthesis of 1-oxaspiro[4.n]alkanes and tetrahydrofurans by the 1,5-CH insertion reaction of magnesium carbenoids

1-Alkoxy-1-[2-chloro-2-(p-tolylsulfinyl)ethyl]cycloalkanes were prepared from various cyclic ketones in good overall yields. Treatment of these cycloalkanes bearing a sulfinyl group with i-PrMgCl resulted in the formation of 1-oxaspiro[4.n]alkanes in high to quantitative yields via the 1,5-CH insertion reaction of generated magnesium carbenoid intermediates. When this procedure was commenced with acyclic ketones, multi-substituted tetrahydrofurans were obtained in up to a 96% yield. This procedure provides a new and good way for the synthesis of 1-oxaspiro[4.n]alkanes and tetrahydrofurans with the formation of a carbon-carbon bond between a carbenoid carbon and a non-activated carbon in high yields. The oxygen atom in the magnesium carbenoid intermediates was proved to act very important roles in the 1,5-CH insertion reaction.

OXADIAZOLIDINEDIONE COMPOUND

[Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided. [Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.