83242-35-7

Upstream product

• 83242-28-8 (R)-3-Chloromethyl-2-[(2R,3R)-2-(5-methyl-[1,3,4]thiadiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid benzyl ester 
• 82895-21-4 (6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 
• 29490-19-5 2-mercapto-5-methyl-1,3,4-thiadiazole 
• 86832-59-9 (R)-2-((1R,5R)-3-Benzyl-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid benzyl ester 
• 83290-69-1 (R)-2-((1R,5R)-3-Benzyl-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-chloromethyl-but-3-enoic acid benzyl ester 
• 80405-20-5 (R)-2-[(1R,5R)-3-(Dichloro-phenyl-methyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl]-3-methyl-but-3-enoic acid benzyl ester 
• 86832-60-2 (R)-3-Chloromethyl-2-[(1R,5R)-3-(dichloro-phenyl-methyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl]-but-3-enoic acid benzyl ester 

Relevant academic research and scientific papers

PENICILLIN-CEPHALOSPORIN CONVERSION IV. DIRECT SYNTHESIS OF 3'-THIOSUBSTITUTED CEPHALOSPORINS FROM THIAZOLE-AZETIDINONES

Direct transformation of thiazoline-azetidinones 2, derived from penicillin G and V, into 3'-thio-substituted cephalosporins 4 has been performed by ring opening of the thiazoline moiety with sulfenyl chlorides followed by ring closure with NH3 in dimethy