82895-21-4

Upstream product

• 95463-15-3 3-Chloromethyl-2-[2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid benzyl ester 
• 93861-47-3 2-(2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-methyl-but-3-enoic acid benzyl ester 
• 93861-48-4 benzyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinon-1-yl]-3-methyl-3-butenoate 
• 82895-18-9 (R)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-chloromethyl-but-3-enoic acid benzyl ester 
• 86832-59-9 (R)-2-((1R,5R)-3-Benzyl-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-methyl-but-3-enoic acid benzyl ester 
• 83290-69-1 (R)-2-((1R,5R)-3-Benzyl-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-chloromethyl-but-3-enoic acid benzyl ester 
• 80405-20-5 (R)-2-[(1R,5R)-3-(Dichloro-phenyl-methyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl]-3-methyl-but-3-enoic acid benzyl ester 
• 82895-11-2 (R)-3-Methyl-2-[(2R,3R)-2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid benzyl ester 
• 82895-12-3 (R)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-methyl-but-3-enoic acid benzyl ester 
• 86832-60-2 (R)-3-Chloromethyl-2-[(1R,5R)-3-(dichloro-phenyl-methyl)-7-oxo-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl]-but-3-enoic acid benzyl ester 
• 82895-17-8 (R)-3-Chloromethyl-2-[(2R,3R)-2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid benzyl ester 
• 83242-28-8 (R)-3-Chloromethyl-2-[(2R,3R)-2-(5-methyl-[1,3,4]thiadiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid benzyl ester 
• 95406-21-6 2-(2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-chloromethyl-but-3-enoic acid benzyl ester 

Downstream Products

• 34708-39-9 (6R)-3-methyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 
• 83242-35-7 (6R,7R)-3-(5-Methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

PENICILLIN-CEPHALOSPORIN CONVERSION IV. DIRECT SYNTHESIS OF 3'-THIOSUBSTITUTED CEPHALOSPORINS FROM THIAZOLE-AZETIDINONES

Direct transformation of thiazoline-azetidinones 2, derived from penicillin G and V, into 3'-thio-substituted cephalosporins 4 has been performed by ring opening of the thiazoline moiety with sulfenyl chlorides followed by ring closure with NH3 in dimethy

PENICILLIN-CEPHALOSPORIN CONVERSION III. A NOVEL ROUTE TO 3-CHLOROMETHYL-Δ3-CEPHEMS

Synthesis of 3-chloromethyl-Δ3-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achived by the electrolytic ene-type chlorination of 1 in a CHCl3-aqueous NaCl-H2SO4-(Pt electrodes) system and subse