83245-91-4Relevant academic research and scientific papers
Iodine-Promoted Semmler–Wolff Reactions: Step-Economic Access to meta-Substituted Primary Anilines via Aromatization
Wang, Shi-Ke,You, Xia,Zhao, Da-Yuan,Mou, Neng-Jie,Luo, Qun-Li
supporting information, p. 11757 - 11760 (2017/09/07)
An atom- and step-economic access to an array of unprotected meta-substituted primary anilines was disclosed using the Semmler–Wolff reaction, promoted by molecular iodine. Therein, noble metal catalysts and inert atmosphere are unnecessary while the forcing reaction conditions and the lengthy synthesis can be avoided. The synthetic utility of this approach is evident in the de novo syntheses of three bioactive molecules with good total yields.
SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
-
, (2014/03/25)
The invention provides certain substituted phenyl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
Palladium-catalyzed dehydrative aromatization of cyclohexenone oximes to anilines
Matsumoto,Tomizuka,Suzuki
, p. 1441 - 1446 (2007/10/02)
Cyclohexenone oximes were smoothly dehydrated to the corresponding anilines by the catalysis of palladium on carbon.
