83249-56-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate is used as a pharmaceutical compound for its potential therapeutic properties. Its unique structure, including the presence of iodine atoms and the methoxyphenoxy group, may contribute to its biological activity and efficacy in treating certain medical conditions.
Used in Organic Synthesis:
In the field of organic synthesis, Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate can be used as a building block or intermediate in the synthesis of more complex organic molecules. Its versatile structure allows for further functionalization and modification, enabling the development of new compounds with desired properties.
Used as a Research Reagent:
Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate can also serve as a research reagent in various scientific studies. Its unique structure and potential properties make it an interesting subject for investigation, allowing researchers to explore its chemical behavior, reactivity, and potential applications in different areas of chemistry and biology.

InChI:InChI=1/C20H21I2NO5/c1-4-27-20(25)18(23-12(2)24)11-13-9-16(21)19(17(22)10-13)28-15-7-5-14(26-3)6-8-15/h5-10,18H,4,11H2,1-3H3,(H,23,24)

Upstream product

• 21959-36-4 N-acetyl-3,5-diiodo-L-tyrosine ethyl ester 
• 19231-06-2 4,4'-dimethoxy-diphenyliodonium bromide 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1027-28-7 N-acetyl-3,5-diiodo-L-tyrosine 
• 300-39-0 3,5-diiodo-l-tyrosine 
• 440667-78-7 3.5-diamino-O'-methyl-N-acetyl-L-thyronine ethyl ester 
• 60-18-4 L-tyrosine 
• 83290-90-8 3.5-dinitro-O'-methyl-N-acetyl-L-thyronine ethyl ester 
• 17360-11-1 NSC 80662 
• 29358-99-4 N-acetyl-3,5-dinitro-L-tyrosine ethyl ester 
• 20767-00-4 3.5-Dinitro-N-acetyl-L-tyrosin 
• 64-17-5 ethanol 
• 886203-79-8 N-acetyl-3,5-diiodo-O'-methyl-L-thyronine 

Downstream Products

• 102459-99-4 N-acetyl-3,5-dicyano-O'-methyl-L-thyronine ethyl ester 
• 903509-05-7 N-acetyl-3,5-diiodo-O'-methyl-3',5'-dinitro-L-thyronine ethyl ester 
• 94345-95-6 2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid 
• 886203-79-8 N-acetyl-3,5-diiodo-O'-methyl-L-thyronine 
• 93317-08-9 5-((S)-2-amino-2-carboxy-ethyl)-2-(4-hydroxy-phenoxy)-isophthalic acid 
• 42966-10-9 3,5-diiodo-3',5'-dinitro-L-thyronine 
• 1041-01-6 3,5-diiodo-L-thyronine 
• 55-03-8 L-thyroxine sodium 

Relevant academic research and scientific papers

Preparation method of levothyroxine sodium

The invention belongs to the field of pharmaceutical synthesis, and discloses a preparation method of levothyroxine sodium. The preparation method comprises the following steps: (1) taking 3,5-diiodo-L-tyrosine as a raw material, and preparing N-acetyl-L-tyrosine by firstly introducing acetyl protection to an amino group; (2) then preparing N-acetyl-3,5-diiodo-L-tyrosine ethyl ester under the action of thionyl chloride; (3) preparing N-acetyl-O-(4-methyoxyphenyl)-3,3-diiodo-L-tyrosine ethyl ester by carrying out Chan-Lam reaction through copper catalysis; (4) removing a protective group undera strong acidity condition, thus obtaining O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine; (5) then reacting with iodine, and preparing O-(4-hydroxy-3,5-diiodo phenyl)-3,5-diiodo-L-tyrosine disodium salt under the action of sodium hydroxide; (6) finally, regulating pH (Potential of Hydrogen) through glacial acetic acid, thus obtaining the levothyroxine sodium. According to the preparation method disclosed by the invention, the key Chan-Lam reaction and other reaction steps are optimized, so that the reaction time can be greatly shortened, and the reaction yield can be increased; the preparation method is simple in technology, convenient to operate and suitable for industrial production.

Synthesis of diaryl ethers through the copper-promoted arylation of phenols with arylboronic acids. An expedient synthesis of thyroxine

Diaryl ethers are readily synthesized in high yield at room temperature through the copper(II)-promoted coupling of arylboronic acids and phenols. The reaction is tolerant of a wide range of substituents on both coupling partners. These reaction condition