83249-56-3

Basic information

• Product Name: Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate
• Synonyms: Ac-3,5-diiodo-4-(4-methoxyphenoxy)-Phe-OEt;3,5-Diiodo-4-(p-methoxyphenoxy)-N-acetyl-L-phenylalanineethylester;3,5-Diiodo-4-(4-methoxyphenoxy)-N-acetyl-L-phenylalanine ethyl ester;Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate;2-acetamido-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propionic acid ethyl ester;ethyl 2-acetamido-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate
• CAS NO: 83249-56-3
• Molecular Formula: C₂₀H₂₁I₂NO₅
• Molecular Weight: 609.19
• Mol File: 83249-56-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 608 °C at 760 mmHg
• Flash Point: 321.5 °C
• Appearance: /
• Density: 1.724g/cm³
• Vapor Pressure: 9.97E-15mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate(83249-56-3)
• EPA Substance Registry System: Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate(83249-56-3)

Safety Data

• Hazardous Substances Data: 83249-56-3(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate is a chemical compound with the molecular formula C19H20I2NO5. It is a complex organic molecule that consists of an acetylamino group attached to a propanoate chain, which in turn is connected to a phenyl ring substituted with two iodine atoms and a methoxyphenoxy group. Ethyl 2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate may have potential applications in pharmaceuticals, organic synthesis, or as a research reagent. Its precise properties and potential uses would require further investigation and analysis by researchers and chemists.

InChI:InChI=1/C20H21I2NO5/c1-4-27-20(25)18(23-12(2)24)11-13-9-16(21)19(17(22)10-13)28-15-7-5-14(26-3)6-8-15/h5-10,18H,4,11H2,1-3H3,(H,23,24)

Upstream product

• 1027-28-7 N-acetyl-3,5-diiodo-L-tyrosine 
• 300-39-0 3,5-diiodo-l-tyrosine 
• 60-18-4 L-tyrosine 
• 83290-90-8 3.5-dinitro-O'-methyl-N-acetyl-L-thyronine ethyl ester 
• 17360-11-1 NSC 80662 
• 29358-99-4 N-acetyl-3,5-dinitro-L-tyrosine ethyl ester 
• 20767-00-4 3.5-Dinitro-N-acetyl-L-tyrosin 
• 5720-07-0 4-methoxyphenylboronic acid 
• 21959-36-4 N-acetyl-3,5-diiodo-L-tyrosine ethyl ester 
• 440667-78-7 3.5-diamino-O'-methyl-N-acetyl-L-thyronine ethyl ester 
• 19231-06-2 4,4'-dimethoxy-diphenyliodonium bromide 
• 64-17-5 ethanol 
• 886203-79-8 N-acetyl-3,5-diiodo-O'-methyl-L-thyronine 

Downstream Products

• 102459-99-4 N-acetyl-3,5-dicyano-O'-methyl-L-thyronine ethyl ester 
• 903509-05-7 N-acetyl-3,5-diiodo-O'-methyl-3',5'-dinitro-L-thyronine ethyl ester 
• 94345-95-6 2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid 
• 886203-79-8 N-acetyl-3,5-diiodo-O'-methyl-L-thyronine 
• 1041-01-6 3,5-diiodo-L-thyronine 
• 55-03-8 L-thyroxine sodium 
• 42966-10-9 3,5-diiodo-3',5'-dinitro-L-thyronine 
• 93317-08-9 5-((S)-2-amino-2-carboxy-ethyl)-2-(4-hydroxy-phenoxy)-isophthalic acid 

Relevant articles and documents

Preparation method of levothyroxine sodium

The invention belongs to the field of pharmaceutical synthesis, and discloses a preparation method of levothyroxine sodium. The preparation method comprises the following steps: (1) taking 3,5-diiodo-L-tyrosine as a raw material, and preparing N-acetyl-L-tyrosine by firstly introducing acetyl protection to an amino group; (2) then preparing N-acetyl-3,5-diiodo-L-tyrosine ethyl ester under the action of thionyl chloride; (3) preparing N-acetyl-O-(4-methyoxyphenyl)-3,3-diiodo-L-tyrosine ethyl ester by carrying out Chan-Lam reaction through copper catalysis; (4) removing a protective group undera strong acidity condition, thus obtaining O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine; (5) then reacting with iodine, and preparing O-(4-hydroxy-3,5-diiodo phenyl)-3,5-diiodo-L-tyrosine disodium salt under the action of sodium hydroxide; (6) finally, regulating pH (Potential of Hydrogen) through glacial acetic acid, thus obtaining the levothyroxine sodium. According to the preparation method disclosed by the invention, the key Chan-Lam reaction and other reaction steps are optimized, so that the reaction time can be greatly shortened, and the reaction yield can be increased; the preparation method is simple in technology, convenient to operate and suitable for industrial production.