83253-77-4

Upstream product

• 10409-54-8 2-bromo-2-methyl-1-phenyl-propan-1-one 
• 104-47-2 p-methoxybenzylnitrile 
• 14491-02-2 2,2-dimethyl-3-phenyl-2H-azirine 
• 7473-98-5 2-hydroxy-2-methylpropiophenone 
• 83253-71-8 (3,3-Dimethyl-2-phenyl-aziridin-2-yl)-(4-methoxy-phenyl)-acetic acid 
• 104-01-8 4-Methoxyphenylacetic acid 
• 83253-86-5 4-Amino-3-(4-methoxy-phenyl)-5,5-dimethyl-4-phenyl-dihydro-furan-2-one 
• 19924-43-7 3-methoxyphenylacetonitrile 

Relevant academic research and scientific papers

Copper-Catalyzed [2 + 3] Cyclization of α-Hydroxyl Ketones and Arylacetonitriles: Access to Multisubstituted Butenolides and Oxazoles

A copper-catalyzed [2 + 3] formal cyclization reaction between α-hydroxyl ketones and arylacetonitriles has been developed. The reaction outcome was ultimately dependent on the structure of the α-hydroxy ketones employed. Tertiary α-hydroxy ketones gave 3,4,5,5-tetrasubstituted butenolides as the sole products, while secondary α-hydroxy ketones furnished 2,4,5-trisubstituted oxazoles selectively. This method has many advantages, such as the use of easily available substrates, broad substrate scope, good functional tolerance, and milder reaction conditions.

Arene Hydrides, 8. - SET vs. Nucleophilic Attack in Reactions of α-Bromoisobutyrophenone with Carbanions. Fragmentation of the Anion of Tetrahydrobianthracene

SET is the main reaction pathway between α-bromoisobutyrophenone (1) and the carbanions 7a-j- of diarylmethanes or disubstituted acetonitriles: 7- 7. + e and e + 1 Br- PhCOCMe2. (3).Main secon

ADDITION DE REACTIFS AMBIDENTS DIMETALLIQUES A LA DOUBLE LIAISON AZIRINIQUE

The Ivanov magnesium reagents obtained from aryl-acetic acids add to 3,3-dimethyl-2-phenyl azirine to give β-aziridino acids 4, which are easily transformed into 4-amino lactones 10 and further into butenolides 11.If sodium is substituted for magnesium th