268550-48-7

Basic information

• Product Name: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE
• Synonyms: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE;TERT-BUTYL 1-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE;2,8-Diazaspiro[4.5]decane-8-carboxylicacid,1-oxo-,1,1-dimethylethylester;1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester;1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester;1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate;8-Boc-1-oxo-2,8-diazaspiro[4.5]decane;tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carbo
• CAS NO: 268550-48-7
• Molecular Formula: C₁₃H₂₂N₂O₃
• Molecular Weight: 254.33
• Mol File: 268550-48-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 424.9°C at 760 mmHg
• Flash Point: 210.8°C
• Appearance: /
• Density: 1.15
• Vapor Pressure: 2E-07mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: 2-8°C
• PKA: 16.00±0.20(Predicted)
• CAS DataBase Reference: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE(268550-48-7)
• EPA Substance Registry System: 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE(268550-48-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 268550-48-7(Hazardous Substances Data)

Usage

General Description

1-BOC-4-Spiro-[3-(2-pyrrolidinone)] piperidine is a chemical compound that belongs to the piperidine class of organic compounds. It is a heterocyclic compound containing a piperidine ring and a pyrrolidinone moiety. The compound also contains a BOC (tert-butoxycarbonyl) protecting group, which is commonly used to temporarily protect amine functional groups in organic synthesis. 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE has potential applications in pharmaceutical and organic synthesis as a building block for the creation of other more complex compounds. Its unique structure and reactivity make it a valuable intermediate for the production of various chemicals and pharmaceuticals.

InChI:InChI=1/C13H22N2O3/c1-12(2,3)18-11(17)15-8-5-13(6-9-15)4-7-14-10(13)16/h4-9H2,1-3H3,(H,14,16)

Upstream product

• 495414-81-8 4-(cyanomethyl)piperidine-1,4-dicarboxylic acid O₁-tert-butyl O₄-ethyl ester 
• 498-94-2 isonipecotic acid 
• 2971-79-1 isonipecotic acid methyl ester 
• 832710-65-3 2,8-diaza-spiro[4.5]decan-1-one hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 1350475-42-1 1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate 
• 268550-47-6 C₁₅H₂₆N₄O₄ 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 212782-43-9 1-tert-butyl 4-ethyl 4-(2-chloroethyl)piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 

Downstream Products

• 1056167-65-7 2-(4-chloro-3-methoxy-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 832710-55-1 2-(4-bromobenzyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 1409968-55-3 C₂₇H₂₉FN₂O 
• 546086-95-7 2,8-diazaspiro[4,5]decane-1-one 
• 832710-65-3 2,8-diaza-spiro[4.5]decan-1-one hydrochloride 

Relevant articles and documents

Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents

A series of 2,8-diazaspiro[4.5]decan-1-one derivatives were designed, synthesized and screened for their inhibition activities against chitin synthase (CHS) and antimicrobial activities in vitro. The biological assays revealed that compounds 4a, 4e, 4h, 4j, 4o, 4q and 4r exhibited moderated to excellent potency against CHS with IC50 values ranging from 0.12 to 0.29 mM. Compounds 4e, 4j with IC50 value of 0.13 mM, 0.12 mM respectively, showed excellent inhibition potency among these compounds, which were similar to that of polyoxin B whose IC50 value was 0.08 mM. Meanwhile, the screening of the antifungal activity showed that compounds 4j and 4r had the same potency of inhibiting the growth of A. fumigatus with MIC value of 0.08 mmol/L. Compound 4d displayed excellent activity against C. albicans (ATCC 90023) with MIC value of 0.04 mmol/L, which was superior to fluconazole (0.104 mmol/L) and polyoxin B (0.129 mmol/L). The result of antibacterial assay showed that these compounds had little potency against those selected bacteria strains including three Gram-positive bacteria and three Gram-negative bacteria. Furthermore, the combination use of 4c-fluconazole, 4i-fluconazole, 4j-fluconazole, and 4o-fluconazole against C. albicans,A. fumigatus and A. flavus showed additive or synergistic effects. These results indicated that the designed compounds serve as potential chitin synthase inhibitors and have selectively antifungal activities.

INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL

Compounds of Formula I and the pharmaceutically acceptable salts thereof are provided as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.