832712-90-0

Upstream product

• 598-32-3 2-hydroxy-3-butene 
• 576-22-7 2-Bromo-m-xylene 
• 86347-16-2 4t-(2,6-dimethyl-phenyl)-but-3-en-2-one 
• 1123-56-4 2,6-dimethylbenzaldehyde 
• 86347-16-2 C₁₂H₁₄O 

Downstream Products

• 832712-93-3 (E)-5-(2,6-Dimethyl-phenyl)-3-methyl-pent-2-enoic acid methyl ester 
• 868136-09-8 C₁₃H₁₅F₃O₃S 
• 868136-10-1 C₂₆H₃₄O₆ 
• 868136-11-2 UTKO₅ 
• 832712-97-7 (E)-5-(2,6-Dimethyl-phenyl)-3-methyl-pent-2-en-1-ol 
• 832713-01-6 (E)-5-(2,6-Dimethyl-phenyl)-3-methyl-pent-2-enal 

Relevant academic research and scientific papers

Controlling olefin isomerization in the heck reaction with neopentyl phosphine ligands

The use of neopentyl phosphine ligands was examined in the coupling of aryl bromides with alkenes. Di-tert-butylneopentylphosphine (DTBNpP) was found to promote Heck couplings with aryl bromides at ambient temperature. In the Heck coupling of cyclic alkenes, the degree of alkene isomerization was found to be controlled by the choice of ligand with DTBNpP promoting isomerization to a much greater extent than trineopentylphosphine (TNpP). Under optimal conditions, DTBNpP provides high selectivity for 2-aryl-2,3-dihydrofuran in the arylation of 2,3-dihydrofuran, whereas TNpP provided high selectivity for the isomeric 2-aryl-2,5-dihydrofuran. A similar complementary product selectivity is seen in the Heck coupling of cyclopentene. Heck coupling of 2-bromophenols or 2-bromoanilides with 2,3-dihydrofurans affords 2,5-epoxybenzoxepin and 2,5-epoxybenzazepins, respectively.

Synthesis and anti-migrative evaluation of moverastin derivatives

Cell migration of tumor cells is essential for invasion of the extracellular matrix and for cell dissemination. Inhibition of the cell migration involved in the invasion process represents a potential therapeutic approach to the treatment of tumor metastasis; therefore, a novel series of derivatives of moverastins (moverastins A and B), an inhibitor of tumor cell migration, was designed and chemically synthesized. Among these moverastin derivatives, several compounds showed stronger cell migration inhibitory activity than parental moverastins, and UTKO1 was found to have the most potent inhibitory activity against the migration of human esophageal tumor EC17 cells in a chemotaxis cell chamber assay. Interestingly, although moverastins are considered to inhibit tumor cell migration by inhibiting farnesyltransferase (FTase), UTKO1 did not inhibit FTase, indicating that UTKO1 inhibited tumor cell migration by a mechanism other than the inhibition of FTase.

Bioluminescence activity of Latia luciferin analogues: Replacement of the 2,6,6-trimethylcyclohexene ring onto the methyl-substituted phenyl groups

Latia luciferin methyl-substituted phenyl analogues were moderately recognized by Latia luciferase with the same light production kinetics and the bioluminescence spectra as that of natural luciferin. A series of Latia luciferin analogues having methyl-su