86347-16-2

Upstream product

• 2039-90-9 2,6-dimethylstyrene 
• 64-19-7 acetic acid 
• 1123-56-4 2,6-dimethylbenzaldehyde 
• 576-22-7 2-Bromo-m-xylene 
• 78-94-4 methyl vinyl ketone 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 

Downstream Products

• 832712-90-0 4-(2,6-dimethylphenyl)butan-2-one 
• 868136-09-8 C₁₃H₁₅F₃O₃S 
• 868136-10-1 C₂₆H₃₄O₆ 
• 868136-11-2 UTKO₅ 
• 832712-93-3 (E)-5-(2,6-Dimethyl-phenyl)-3-methyl-pent-2-enoic acid methyl ester 
• 832712-97-7 (E)-5-(2,6-Dimethyl-phenyl)-3-methyl-pent-2-en-1-ol 
• 832713-01-6 (E)-5-(2,6-Dimethyl-phenyl)-3-methyl-pent-2-enal 

Relevant academic research and scientific papers

Synthesis and anti-migrative evaluation of moverastin derivatives

Cell migration of tumor cells is essential for invasion of the extracellular matrix and for cell dissemination. Inhibition of the cell migration involved in the invasion process represents a potential therapeutic approach to the treatment of tumor metastasis; therefore, a novel series of derivatives of moverastins (moverastins A and B), an inhibitor of tumor cell migration, was designed and chemically synthesized. Among these moverastin derivatives, several compounds showed stronger cell migration inhibitory activity than parental moverastins, and UTKO1 was found to have the most potent inhibitory activity against the migration of human esophageal tumor EC17 cells in a chemotaxis cell chamber assay. Interestingly, although moverastins are considered to inhibit tumor cell migration by inhibiting farnesyltransferase (FTase), UTKO1 did not inhibit FTase, indicating that UTKO1 inhibited tumor cell migration by a mechanism other than the inhibition of FTase.

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

Bioluminescence activity of Latia luciferin analogues: Replacement of the 2,6,6-trimethylcyclohexene ring onto the methyl-substituted phenyl groups

Latia luciferin methyl-substituted phenyl analogues were moderately recognized by Latia luciferase with the same light production kinetics and the bioluminescence spectra as that of natural luciferin. A series of Latia luciferin analogues having methyl-su

Antihypertensive substituted imidazole derivatives

The invention provides novel compounds of the formula: STR1 wherein the various substituents are defined herein below. Processes for the preparation of these compounds are described, as are novel pharmaceutical compositions comprising at least one of the compounds of their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are useful in the treatment of mammals, especially as antihypertensive agents. Furthermore, some of the compounds have proved to possess antithrombotic and diuretic activity. Antimycotic and antifungal properties have also been found.