832719-98-9Relevant academic research and scientific papers
Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase
Tanaka, Rie,Sakano, Yuichi,Nagatsu, Akito,Shibuya, Masaaki,Ebizuka, Yutaka,Goda, Yukihiro
, p. 159 - 162 (2005)
Digalactosyl and monogalactocyl diacylglycerols, were synthesized. DGDG with two myristoyl groups at both sn-1 and sn-2 positions showed the most potent inhibitory activity on human lanosterol synthase. Digalactosyl and monogalactocyl diacylglycerols (DGDG and MGDG), which were identified as anti-hyperlipemia active components in Colocasia esculenta (Taro), were synthesized. The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. DGDG with two myristoyl groups at both sn-1 and sn-2 positions and with an oleoyl group at the sn-1 position showed the most potent activity.
