Bioorganic and Medicinal Chemistry Letters p. 159 - 162 (2005)
Update date:2022-08-04
Topics:
Tanaka, Rie
Sakano, Yuichi
Nagatsu, Akito
Shibuya, Masaaki
Ebizuka, Yutaka
Goda, Yukihiro
Digalactosyl and monogalactocyl diacylglycerols, were synthesized. DGDG with two myristoyl groups at both sn-1 and sn-2 positions showed the most potent inhibitory activity on human lanosterol synthase. Digalactosyl and monogalactocyl diacylglycerols (DGDG and MGDG), which were identified as anti-hyperlipemia active components in Colocasia esculenta (Taro), were synthesized. The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. DGDG with two myristoyl groups at both sn-1 and sn-2 positions and with an oleoyl group at the sn-1 position showed the most potent activity.
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