832746-77-7

Basic information

• Product Name: 4-difluoromethyl-3-methyl-1-phenyl-6,7-di-hydro-1H-pyrazolo[3,4-b]pyridin-6-one
• Synonyms: 4-difluoromethyl-3-methyl-1-phenyl-6,7-di-hydro-1H-pyrazolo[3,4-b]pyridin-6-one
• CAS NO: 832746-77-7
• Molecular Weight: 275.258
• Mol File: 832746-77-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-difluoromethyl-3-methyl-1-phenyl-6,7-di-hydro-1H-pyrazolo[3,4-b]pyridin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-difluoromethyl-3-methyl-1-phenyl-6,7-di-hydro-1H-pyrazolo[3,4-b]pyridin-6-one(832746-77-7)
• EPA Substance Registry System: 4-difluoromethyl-3-methyl-1-phenyl-6,7-di-hydro-1H-pyrazolo[3,4-b]pyridin-6-one(832746-77-7)

Safety Data

• Hazardous Substances Data: 832746-77-7(Hazardous Substances Data)

Upstream product

• 1131-18-6 1-Phenyl-3-methyl-5-aminopyrazole 
• 1350908-57-4 4-[(bromo)(difluoro)methyl]-3-methyl-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4 b]pyridin-6-one 
• 106-54-7 p-Chlorothiophenol 
• 106-45-6 para-thiocresol 
• 108-98-5 thiophenol 
• 352-24-9 ethyl 4,4-difluoro-3-oxobutyrate 

Relevant articles and documents

Synthesis of new fluorine-containing pyrazolo[3,4-b]pyridinones as promising drug precursors

Methods for the synthesis of 4-R-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6- ones (R = CF2SAr and 4-CFHSAr) were developed. The derivatives with R = CF2SAr were obtained by both heterocyclization of 1-substituted 5-aminopyrazoles with ethyl 4,4-difluoro-3-oxo-4-phenylsulfanylbutanoate and replacement of the Br atom in 4-bromodifluoromethyl-6,7-dihydro-1H-pyrazolo[3,4- b]pyridin-6-ones by sodium arenethiolates. The fragment 4-CF-HSAr was introduced by replacement of the Cl atom in 4-chlorofluoromethyl-6,7-dihydro-1H- pyrazolo[3,4-b]pyridin-6-ones by sodium arenethiolates. Oxidation of 4-CF 2SPh-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-6-ones gave the corresponding sulfoxides; their structures were confirmed by X-ray diffraction data.