83280-13-1Relevant academic research and scientific papers
Myelopeptide MP-5 and fluorescent derivatives: Synthesis and biological activity
Fonina,Az'muko,Kalikhevich,Lewit,Ardemasova,Gur'yanov,Belevskaya,Efremov,Treshchalina,Mikhailova
, p. 404 - 408 (2008/12/21)
The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and its analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The iological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60-84% inhibition of growth of the following mouse cancers: lymphatic leukemia P388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T-lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 towards T-lymphocytes, but Ftc-MP-5 was practically inactive.
Synthesis and anti-inflammatory activity of acetylsalicylamino acids and peptides
Khalikov,Kodirov,Alieva
, p. 204 - 207 (2008/02/01)
Several water-soluble acetylsalicylamino acids and peptides containing neutral and acidic amino acids were synthesized and investigated for anti-inflammatory activity. 2006 Springer Science+Business Media, Inc.
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF NEW ANALOGUES OF β-CASOMORPHINE-5*
Sobirov, M.M.,Khalikov, Sh.Kh.,Saidov, S.S.,Kodirov, M.Z.,Zaitsev, S.V.,et al.
, p. 397 - 405 (2007/10/02)
Four new analogues of β-casomorphine-5 modified at the C-end by modifiers based on ethylenediamine and glycine residues have been synthesized. the opioid and analgesic activities of the peptides obtained comparison with β-casomorphine-5 and morphine are discussed.
