83286-37-7

Upstream product

• 83286-30-0 2-(2-furyl)-4,5-dihydro-4,4-dimethyl-1,3-oxazole 
• 100-52-7 benzaldehyde 
• 527-69-5 2-furancarbonyl chloride 
• 88-14-2 2-furanoic acid 
• 83286-35-5 N-(1,1-dimethyl-2-hydroxyethyl)furan-2-carboxamide 

Relevant academic research and scientific papers

Regioselective β-Metallation of 2-Substituted Furan and N-Methylpyrrole Derivatives Employing the Directing Effect of the Oxazolino Group: Syntheses of 2,3-Disubstituted Furans and N-Methylpyrroles

The effects of change of solvent and reaction time, of addition of Li+-chelating agent, and in some instances, of change of temperature and metallating agent, on the metallation of 2-(2-furyl)- and 2-(N-methylpyrrol-2-yl)-oxazolines by alkyl-lithium reagents are explored.Conditions are thereby established for high-yielding syntheses of lithio-intermediates and for control of regioselectivity of metallation.Syntheses of pure samples of 2-(3-hydroxyphenylmethyl-2-furyl)-, 2-(5-hydroxyphenylmethyl-2-furyl)-, 2-(3-carboxy-N-methylpyrrol-2-yl)- and 2-(5-carboxy-N-methylpyrrol-2-yl)-4,4-dimethyloxazolines, based on the results of these investigation, are reported.