83286-56-0

Usage

Uses

Used in Pharmaceutical Industry:
PHENYL-D5 ISOCYANATE is used as a key intermediate in the synthesis of cyanopyridine derivatives, which are being explored for their potential as anticancer compounds. The incorporation of deuterium atoms in PHENYL-D5 ISOCYANATE aids in the investigation of the metabolic pathways and pharmacokinetics of these derivatives.
Used in Medicinal Chemistry Research:
PHENYL-D5 ISOCYANATE is utilized in the synthesis of aminobenzimidazole derivatives with phenylcyclohexyl acetic groups. These derivatives have demonstrated antiobesity and antidiabetic activity, making them valuable targets for drug development. The use of PHENYL-D5 ISOCYANATE in their synthesis allows for the study of their metabolic stability and potential side effects, ultimately contributing to the optimization of these therapeutic agents.

Upstream product

• 14545-23-4 aniline-d₇ 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 4165-61-1 aniline-d5 
• 1076-43-3 benzene-d6 
• 4165-60-0 nitrobenzene-d5 
• 43019-90-5 benzoyl chloride-d5 
• 1079-02-3 benzoic acid-2,3,4,5,6-d5 

Relevant academic research and scientific papers

The silver-mediated annulation of arylcarbamic acids and nitrosoarenes toward phenazines

A silver-mediated annulation between arylcarbamic acids and nitrosoarenes was developed, leading to phenazines in moderate to good yields with complexity and diversity. This procedure proceeded with the sequential ortho[sbnd] C[sbnd]H functionalization of arylcarbamic acids, insertion to nitroso group and decarboxylative annulation.

Synthesis of Unprotected and Highly Substituted Indoles by the Ruthenium(II)-Catalyzed Reaction of Phenyl Isocyanates with Diaryl/Diheteroaryl Alkynes/Ethyl-3-phenyl Propiolates

A one-pot transformation has been developed for the synthesis of unprotected and highly substituted indoles by an in situ installed carbamide-directed Ru(II)-catalyzed intermolecular oxidative annulation of phenyl isocyanates with diaryl/diheteroaryl alkynes/ethyl phenyl propiolates in the presence of Cu(OAc)2·H2O as an oxidant and AgSbF6 as an additive at 120 °C within 3 h.

Phenyl isocyanate anion radicals and their cyclotrimerization to triphenyl isocyanurate anion radicals

Room-temperature sodium metal reduction of phenyl isocyanate (PhNCO) in hexamethylphosphoramide yields the anion radical (PhNCO?-) where the unpaired electron exhibits coupling to one nitrogen and five unique protons. The extent of coupling to

Investigating N-methoxy-N′-aryl ureas in oxidative C-H olefination reactions: An unexpected oxidation behaviour

Herein, we report a urea derived directing group for mild and highly selective oxidative C-H bond olefination. Subsequent intramolecular Michael addition affords dihydroquinazolinones in good yields. The N-O bond of the urea substrate exhibits superior oxidative behaviour compared to a variety of other external oxidants. The Royal Society of Chemistry 2011.

3,4-Dihydroisoquinolines, II. 4,5,7,8-Tetrahydrocyclopentapyrimidoisoquinoline: A novel Ring System via 1-(3-Furyl)-3,4-dihydroisoquinoline Transformation

Furan (1) readily reacts with excess isocyanate 2a to yield the -adduct 3, which was cyclized under mild conditions to give the fulvene derivative 4a.Reaction of the latter with isocyanate 2b leads to 4c-f.The structures of 3 and 4 are derived from analytical and spectroscopic data and by an X-ray structure analysis (4a).A possible pathway for the formation of 3 and 4a is discussed.