83291-83-2Relevant articles and documents
Synthesis and Topical Antiinflamatory Activity of Some Steroidal Isoxazolidines
Green, Michael J.,Tiberi, Robert L.,Friary, Richard,Lutsky, Barry N.,Berkenkoph, Joseph,et al.
, p. 1492 - 1495 (1982)
1,3-Dipolar cycloaddition of N-methylnitrone, N-benzylnitrone, and pyrroline N-oxide to 1,4,16-pregnatriene-3,20-diones is described.In each case only isoxazolidines were isolated.The pentacyclic adducts 16-19 were active topical antiinflammatory agents in mice, with 18 being more potent than any of the standard compound tested.The hexacyclic adduct 20 was inactive in this assay.