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Usage

Uses

Used in Pharmaceutical Industry:
7-Hydroxycoumarin-6-carboxylic acid is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows it to be a key component in the development of new medications, particularly in the field of cardiovascular and anticoagulant therapies.
Used in Chemical Research:
7-Hydroxycoumarin-6-carboxylic acid serves as a valuable compound in chemical research, particularly in the study of coumarin derivatives and their potential applications. Its structure provides a basis for understanding the properties and reactivity of related compounds, contributing to the advancement of organic chemistry.
Used in Analytical Chemistry:
7-Hydroxycoumarin-6-carboxylic acid is used as a reference material in analytical chemistry for the calibration of instruments and the development of new analytical methods. Its distinct chemical properties make it a reliable standard for comparison and measurement in various chemical analyses.
Used in Material Science:
7-Hydroxycoumarin-6-carboxylic acid is employed as a component in the development of new materials, such as polymers and composites, with potential applications in various industries. Its unique chemical structure contributes to the creation of materials with specific properties, such as improved strength, flexibility, or thermal stability.

Upstream product

• 617-48-1 malic acid 
• 89-86-1 4-hydroxysalicylic acid 
• 52591-14-7 7-hydroxy-6-(methoxycarbonyl)coumarin 

Relevant academic research and scientific papers

Plant Coumarins: XVII. Synthesis and Transformations of 7-Hydroxy-2-oxo-2H-chromene-6-carboxamides

Umbelliferone-6-carbonyl chloride reacted with amines and α-, β-, and ω-amino acid methyl esters to afford the corresponding N-substituted 7-hydroxy-2-oxo-2H-chromene-6-carboxamides. The reaction of umbelliferone-6-carbonyl chloride with glycine gave 2-(7-hydroxy-2-oxo-2H-chromene-6-carboxamido)acetic acid which was converted into acid chloride, and the latter reacted with benzylamines and α-amino acid methyl esters to produce compounds containing a dipeptide fragment.

Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin

Synthesis of 1,2,3-triazole-substituted coumarins and also 1,2,3-triazolyl or 1,2,3-triazolylalk-1-inyl-linked coumarin-2,3-furocoumarin hybrids was performed by employing the cross-coupling and copper catalyzed azide-alkyne cycloaddition reaction approaches. The synthesized compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, Bacillius subtilis, Actinomyces viscosus and Escherichia coli bacterial strains. Coumarin-benzoic acid hybrids 4с, 42с and 3-((4-acetylamino-3-(methoxycarbonyl)phenyl)ethynyl)coumarin (29) showed promising activity against S. aureus strains, and the 1,2,3-triazolyloct-1-inyl linked coumarin-2,3-furocoumarin hybrid 37c was endowed with high selectivity against B. subtilis and E. coli species. The in vitro antibacterial activity of 4с, 29, 37c and 42с can potentially be compared with that of a number of modern antibiotic drugs used in the clinic, suggesting promising prospects for further research. A detailed study of the molecular interactions with the targeted protein MurB was performed using docking simulations and the obtained results are quite promising.