833-52-3

Basic information

• Product Name: 7-Hydroxycoumarin-6-carboxylic acid
• Synonyms: 7-Hydroxycoumarin-6-carboxylic acid;7-Hydroxy-2-oxo-2H-chroMene-6-carboxylic acid
• CAS NO: 833-52-3
• Molecular Formula: C₁₀H₆O₅
• Molecular Weight: 206
• Mol File: 833-52-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 268-269 °C
• Boiling Point: 482.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.609±0.06 g/cm3(Predicted)
• PKA: 2.54±0.20(Predicted)
• CAS DataBase Reference: 7-Hydroxycoumarin-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxycoumarin-6-carboxylic acid(833-52-3)
• EPA Substance Registry System: 7-Hydroxycoumarin-6-carboxylic acid(833-52-3)

Safety Data

• Hazardous Substances Data: 833-52-3(Hazardous Substances Data)

Usage

General Description

7-Hydroxycoumarin-6-carboxylic acid is a chemical compound that falls under the category of coumarins and derivatives. Coumarins are a class of chemicals widely distributed in plants and come from the amino acid phenylalanine. This specific chemical has a molecular formula of C10H6O5 and a molecular weight of 210.152 g/mol. It is a combination of hydroxycoumarin and carboxylic acid. As an organic compound, it includes atoms of carbon, hydrogen, and oxygen. Its uses and properties are specific to its interchange positions of chemical groups and have not been widely studied.

Upstream product

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Relevant articles and documents

Plant Coumarins: XVII. Synthesis and Transformations of 7-Hydroxy-2-oxo-2H-chromene-6-carboxamides

Umbelliferone-6-carbonyl chloride reacted with amines and α-, β-, and ω-amino acid methyl esters to afford the corresponding N-substituted 7-hydroxy-2-oxo-2H-chromene-6-carboxamides. The reaction of umbelliferone-6-carbonyl chloride with glycine gave 2-(7-hydroxy-2-oxo-2H-chromene-6-carboxamido)acetic acid which was converted into acid chloride, and the latter reacted with benzylamines and α-amino acid methyl esters to produce compounds containing a dipeptide fragment.

Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin

Synthesis of 1,2,3-triazole-substituted coumarins and also 1,2,3-triazolyl or 1,2,3-triazolylalk-1-inyl-linked coumarin-2,3-furocoumarin hybrids was performed by employing the cross-coupling and copper catalyzed azide-alkyne cycloaddition reaction approaches. The synthesized compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, Bacillius subtilis, Actinomyces viscosus and Escherichia coli bacterial strains. Coumarin-benzoic acid hybrids 4с, 42с and 3-((4-acetylamino-3-(methoxycarbonyl)phenyl)ethynyl)coumarin (29) showed promising activity against S. aureus strains, and the 1,2,3-triazolyloct-1-inyl linked coumarin-2,3-furocoumarin hybrid 37c was endowed with high selectivity against B. subtilis and E. coli species. The in vitro antibacterial activity of 4с, 29, 37c and 42с can potentially be compared with that of a number of modern antibiotic drugs used in the clinic, suggesting promising prospects for further research. A detailed study of the molecular interactions with the targeted protein MurB was performed using docking simulations and the obtained results are quite promising.