83300-00-9

Upstream product

• 1160596-81-5 [3-(dimethylamino)propyl]triphenylphosphonium chloride hydrochloride 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 603-35-0 triphenylphosphine 

Downstream Products

• 875050-51-4 (E)-methyl 3-[4-(dimethylamino)but-1-enyl]-4-(2-iodobenzyloxy)phenylacetate 
• 1668-19-5 doxepin 

Relevant academic research and scientific papers

Improved synthesis method of doxepin hydrochloride

The invention relates to an improved synthesis method of doxepin hydrochloride. The method comprises the following steps: (1) reacting triphenylphosphine with 3 - chlorine -1 - (N, N - dimethyl) propylamine to prepare (3 - (dimethylamino) propyl) triphenyl phosphine chloride. (2) Reaction of (3 - (dimethylamino) propyl) triphenyl phosphine chloride and 6, 11 -dihydrodibenzo [b, e] oxepin -11 - ketone under a strong base condition to Wittig prepare a doxorubicin. (3) The multi-plug is subjected to salt formation reaction with hydrochloric acid to prepare the doxorubicin hydrochloride. The second Reaction is adopted in Wittig-step reaction, so that the reaction is simpler, the requirements for water and reaction equipment of the solvent and the raw materials are lower, and the repetition rate is higher. Compared with the prior art, the method has the advantages of simple process, low production cost, less process steps and the like.

Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer

Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.

PREPARATION DE SELS D'AMINOALKYLPHOSPHONIUMS

Three synthetic methods have been applied to prepare amino phosphonium salts: (C6H5)3P+-(CH2)n-N-.The best ways have been determined for different n values and different substituents on the nitrogen atom.In all cases, yields are better with n=3, but no intramolecular stabilization has been detected.