875050-51-4

Basic information

• Product Name: (E)-methyl 3-[4-(dimethylamino)but-1-enyl]-4-(2-iodobenzyloxy)phenylacetate
• Synonyms: (E)-methyl 3-[4-(dimethylamino)but-1-enyl]-4-(2-iodobenzyloxy)phenylacetate
• CAS NO: 875050-51-4
• Molecular Weight: 479.358
• Mol File: 875050-51-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-methyl 3-[4-(dimethylamino)but-1-enyl]-4-(2-iodobenzyloxy)phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 3-[4-(dimethylamino)but-1-enyl]-4-(2-iodobenzyloxy)phenylacetate(875050-51-4)
• EPA Substance Registry System: (E)-methyl 3-[4-(dimethylamino)but-1-enyl]-4-(2-iodobenzyloxy)phenylacetate(875050-51-4)

Safety Data

• Hazardous Substances Data: 875050-51-4(Hazardous Substances Data)

Upstream product

• 875050-49-0 methyl [3-formyl-4-(2-iodobenzyloxy)phenyl]acetate 
• 59473-45-9 2-(chloromethyl)iodobenzene 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 
• 61874-04-2 (3-formyl-4-hydroxyphenyl)acetic acid methyl ester 
• 18355-96-9 (3-dimethylaminopropyl)-triphenylphosphoniumbromide 
• 83300-00-9 chlorure de N,N-dimethylamino-3 propyltriphenylphosphonium 

Downstream Products

• 140462-76-6 olopatadine hydrochloride 

Relevant articles and documents

Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer

Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.

PROCESS FOR THE PREPARATION OF 11-[(Z)-3-(DIMETHYLAMINO)PROPYLIDENE]-6,11-DIHYDRO-DIBENZ[B,E]OXEPIN-2-YL]-ACETIC ACID

Process for the preparation of olopatadine (I), which comprises reacting a compound of formula (V) in the presence of a palladium catalyst to provide a compound of formula (VI), wherein the acid protecting group is removed to provide the compound of formula (I) and if desired, transformation into its salts.