83303-96-2

Basic information

• Product Name: 2-(4-chlorophenyl)-N-(2-phenylethyl)acetamide
• CAS NO: 83303-96-2
• Molecular Formula: C₁₆H₁₆ClNO
• Molecular Weight: 273.7573
• Mol File: 83303-96-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 483.4°C at 760 mmHg
• Flash Point: 246.2°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.68E-09mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 2-(4-chlorophenyl)-N-(2-phenylethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-N-(2-phenylethyl)acetamide(83303-96-2)
• EPA Substance Registry System: 2-(4-chlorophenyl)-N-(2-phenylethyl)acetamide(83303-96-2)

Safety Data

• Hazardous Substances Data: 83303-96-2(Hazardous Substances Data)

Usage

Chemical class

Amides

Derivation

Derived from acetamide

Chlorophenyl group

Contains a 4-chlorophenyl group

Phenylethyl group

Contains a 2-phenylethyl group

Attachment

Both groups are attached to the acetamide functional group

Uses

May have various uses in organic synthesis, pharmaceuticals, and industrial applications

Hazards

Potential hazards and adverse effects on human health and the environment

Handling

Should be handled with care

Upstream product

• 64-04-0 phenethylamine 
• 25026-34-0 4-chlorophenacetyl chloride 
• 1878-66-6 4-chlorophenylacetic Acid 
• 100-46-9 benzylamine 

Downstream Products

• 75397-67-0 1-(4-chlorobenzyl)-3,4-dihydroisoquinoline 

Relevant articles and documents

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

Synthesis and Photo-oxygenation of Some Substituted 1-Benzyl-3,4-dihydroisoquinolines. Mechanism of Enamine Photo-oxygenation

The synthesis of a series of substituted 1-benzyl-3,4-dihydroisoquinolines by Bischler-Napieralski cyclization is described.Competitive methylene blue sensitized photo-oxygenation experiments allowed the determination of relative rates of photo-oxygenation of 1-benzyl-3,4-dihydroisoquinolines.Substituents were shown to affect both the equilibrium concentration of the tautomeric enamine and the overall photo-oxygenation rate.After correcting for differences in enamine concentration, the relative rate data provided a diagnostic probe of the reaction mechanism, which involves transfer of charge in the rate-limiting step.