83304-68-1

Upstream product

• 6414-58-0 diethyl 2-phenylaminomalonate 
• 83304-67-0 3-Hydroxy-3-methyl-5-oxo-1-phenyl-pyrrolidine-2,2-dicarboxylic acid diethyl ester 

Downstream Products

• 87542-33-4 (2R,3R)-3-(2-Methyl-[1,3]dioxolan-2-yl)-4-oxo-1-phenyl-azetidine-2-carboxylic acid ethyl ester 
• 87542-33-4 (2R,3S)-3-(2-Methyl-[1,3]dioxolan-2-yl)-4-oxo-1-phenyl-azetidine-2-carboxylic acid ethyl ester 
• 87542-32-3 (S)-3-(2-Methyl-[1,3]dioxolan-2-yl)-4-oxo-1-phenyl-azetidine-2,2-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

SIMPLE AND CONDENSED β-LACTAMS-I. THE APPLICATION OF DIKETENE IN β-LACTAM SYNTHESIS. THE SYNTHESIS AND FUNCTIONAL GROUP MANIPULATIONS OF DIETHYL 3-ACETYL-4-OXOAZETIDINE-2,2-DICARBOXYLATES

Acetylation of the N-substituted diethyl aminomalonates 3a-3d with diketene furnished the ring tautomers 6a-6d of the expected acetoacetyl derivatives 5.By treatment with iodine and sodium ethoxide compounds 6a-6d are smoothly converted into the β-lactam

Beta-lactam compounds containing a C-acetal group and process for their preparation

The invention relates to new heterocyclic compounds containing a C-acetyl group and a process for their preparation. More particularly, the invention concerns new compounds of the formula (III). STR1 in which R is a protecting group suitable for temporary