83304-70-5

Upstream product

• 685-87-0 Diethyl 2-bromomalonate 
• 104-94-9 4-methoxy-aniline 
• 24043-40-1 diethyl 2-[(4-methoxyphenyl)amino]malonate 
• 83304-69-2 3-Hydroxy-1-(4-methoxy-phenyl)-3-methyl-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 

Downstream Products

• 87542-26-5 (2S,3R)-1-(4-Methoxy-phenyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidine-2-carboxylic acid ethyl ester 
• 87542-26-5 (2R,3R)-1-(4-Methoxy-phenyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidine-2-carboxylic acid ethyl ester 
• 87542-25-4 1-(4-Methoxy-phenyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidine-2,2-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

SIMPLE AND CONDENSED β-LACTAMS-I. THE APPLICATION OF DIKETENE IN β-LACTAM SYNTHESIS. THE SYNTHESIS AND FUNCTIONAL GROUP MANIPULATIONS OF DIETHYL 3-ACETYL-4-OXOAZETIDINE-2,2-DICARBOXYLATES

Acetylation of the N-substituted diethyl aminomalonates 3a-3d with diketene furnished the ring tautomers 6a-6d of the expected acetoacetyl derivatives 5.By treatment with iodine and sodium ethoxide compounds 6a-6d are smoothly converted into the β-lactam