83305-62-8Relevant academic research and scientific papers
Manganese-Catalyzed anti-Selective Asymmetric Hydrogenation of α-Substituted β-Ketoamides
Ding, Kuiling,Han, Zhaobin,Wang, Zheng,Zhang, Linli
supporting information, p. 15565 - 15569 (2020/07/06)
A Mn-catalyzed diastereo- and enantioselective hydrogenation of α-substituted β-ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti-α-Substituted β-hydroxy amides, which are useful building blocks for the synthesis of bioactive molecules and chiral drugs, were prepared in high yields with excellent selectivity (up to >99 percent dr and >99 percent ee) and unprecedentedly high activity (TON up to 10000). The origin of the excellent stereoselectivity was clarified by DFT calculations.
The Vilsmeier-Haack Reaction of Isoxazolin-5-ones. Synthesis and Reactivity of 2-(Dialkylamino)-1,3-oxazin-6-ones
Beccalli, Egle M.,Marchesini, Alessandro
, p. 3426 - 3434 (2007/10/02)
The Vilsmeier-Haack reaction on isoxazolin-5-ones gives 2-(dialkylamino)-1,3-oxazin-6-ones, and a reaction path is proposed depending on substitution pattern of the isoxazolin-5-ones studied.A thermal equilibrium between the oxazinones, imino ketenes, and vinyl isocyanates is hypothesized to explain most of the chemical reactivity of the 2-(dialkylamino)-1,3-oxazin-6-ones.
AMMONIUM SALTS IN ALKYLATION. XVIII. ALKYLATION OF ACETOACETAMIDES
Torosyan, G. O.,Gekchyan, G. G.,Babayan, A. T.
, p. 1423 - 1426 (2007/10/02)
Acetoacetamides are alkylated under the conditions of interphase catalysis (liquid-liquid, solid-liqiud) with the formation of high yields of α-alkylacetamides.
