83348-11-2Relevant academic research and scientific papers
N-Arylation of Heterocycles Promoted by Cyclen Derivatives
Zhang, Bao-Hua,Shi, Lan-Xiang,Liu, Si-Jie,Guo, Rui-Xia
, p. 1234 - 1239 (2015)
An efficient copper-catalyzed N-arylation reactions of imidazole, indole, and triazole with aryl or heteroaryl halides using cyclen derivatives as efficient organic base and ligand at moderate temperature have been investigated. The cross-couplings procee
Highly functional group tolerance in copper-catalyzed N-arylation of nitrogen-containing heterocycles under mild conditions
Zhu, Liangbo,Li, Gaocan,Luo, Liang,Guo, Peng,Lan, Jingbo,You, Jingsong
supporting information; experimental part, p. 2200 - 2202 (2009/07/01)
A copper-catalyzed process has been developed for the N-arylation reaction under very mild conditions in the absence of additional ligand. This protocol could not only tolerate an array of thermally sensitive functional groups, but also achieve high chemoselectivity.
CuI/L (L=pyridine-functionalized 1,3-diketones) catalyzed C-N coupling reactions of aryl halides with NH-containing heterocycles
Xi, Zhenxing,Liu, Fenghui,Zhou, Yongbo,Chen, Wanzhi
, p. 4254 - 4259 (2008/09/20)
An efficient copper-catalyzed N-arylation and N-heteroarylation reactions of imidazole, pyrrole, indole, pyrazole, and perimidine with aryl or heteroaryl halides using pyridine-functionalized 1,3-diketone as ligands have been investigated. The ligands bearing pyridyl and 1,3-diketone moieties, which may form chelated Cu(I) species, are inexpensive and readily available. The combination of CuI and 1,3-di(pyridin-2-yl)propane-1,3-dione is very efficient for C-N coupling reactions to afford various N-arylated products in good to excellent yields.
