83348-67-8Relevant academic research and scientific papers
Synthesis of vincaminic acid derivatives
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, (2008/06/13)
Vincaminic acid derivatives of formula (A) STR1 useful in treating cerebral insufficiency, are prepared by reacting 1-ethyl-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizine with the 2,4-DNP hydrazone of ethyl or methyl bromopyruvate followed by (i) reduction of the C=N bond and (ii) simultaneous cyclization with removal of the ketone-protecting group in either order.
