1617-90-9Relevant articles and documents
Ozonation in Alkaloid Chemistry: a Mild and Selective Conversion of Vincadifformine into Vincamine
Danieli, Bruno,Lesma, Giordano,Palmisano, Giovanni,Gabetta, Bruno
, p. 908 - 909 (1981)
Vincamine has been obtained in a 'one-pot' method by ozonation of vincadifformine.
SYNTHESIS OF VINCA ALKALOIDS AND RELATED COMPOUNDS. PART 18. STEREOCHEMICAL INVESTIGATIONS ON SOME INTERMEDIATES LEADING TO (+)-VINCAMINE
Szabo, Lajos,Kolonits, Pal,Kalaus, Gyoergy,Szantay, Csaba,Kalman, Alajos,et al.
, p. 1629 - 1636 (1984)
The C-2' absolute configrations of hydroxy esters (1) and (2) have been determined by X-ray analysis.The absolute configurations at C-15 of several compounds with the E-homoeburnane skeleton and the relative configurations at C-14 and -15 of compound (8) have been elucidated.The dominant conformation of compounds (3)-(7) have been established on the basis of 13C n.m.r. and c.d.spectroscopic results.A new method has been elaborated for the preparation of oxime (10), a compound of importance in the synthesis of Vinca alkaloids.
Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora
Koyama, Koichiro,Hirasawa, Yusuke,Hosoya, Takahiro,Hoe, Teh Chin,Chan, Kit-Lam,Morita, Hiroshi
, p. 4415 - 4421 (2010)
Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alpneumines E and G (5 and 7), vincamine, and apovincamine showed anti-melanogenesis in B16 mouse melanoma cells.
Kuehne
, p. 2946 (1964)
Synthesis of vinca alkaloids and related compounds LX. A simple transformation of apovincamine into vincamine
Moldvai, Istvan,Szantay Jr., Csaba,Rissanen, Kari,Szantay, Csaba
, p. 4999 - 5008 (1992)
The 15α-chloro-vincamine derivative 2 was prepared and proved to be key intermediate of a two-step transformation of apovincamine into vincamine. The structure of 2 was established via detailed NMR and X-ray investigations.
Preparation method of vincamine
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Paragraph 0044-0047, (2021/04/21)
The invention provides a green preparation method of vincamine, which comprises the following steps: (1) reduction: introducing a tabersonine methanol solution and hydrogen into a micro-channel reactor through a charging pump to react, and filtering, concentrating and extracting the reaction solution twice after the reaction is finished, thereby obtaining an extracting solution; (2) oxidation: catalyzing an organic phase in the extraction liquid in the step (1) by using peroxy acid to carry out oxidation reaction, neutralizing by using a sodium bicarbonate solution after the reaction is finished, extracting and concentrating; and (3) rearrangement: dissolving the concentrated solid obtained in the step (2) with ethanol, rearranging in the presence of a catalyst, adjusting the pH value after the reaction is completed, filtering, washing and crystallizing the filter cake, and separating out the solid, namely vincamine. The preparation method is safe, environmentally friendly and capable of achieving continuous production, the product purity is 99% or above, automatic equipment can be adopted for continuous production, and the industrial production efficiency is improved.
Preparation method of high-purity vinpocetine (by machine translation)
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Paragraph 0041; 0043-0044; 0051-0056, (2020/04/17)
The preparation method, of the high-purity vinpocetine :S1. comprises, following steps: preparing vinpocstine, by dissolving; in toluene as a solvent; in toluene as a solvent ;S2. and carrying out an ester exchange reaction, to obtain the intermediate vinpocstine nitrogen oxide, in a toluene as a solvent, and carrying out an ester exchange reaction to obtain a product impurity at least ;S3. purity S2 and, % by mass of a solvent . The preparation method of the vinpocstine nitrogen oxide reaction solution in step, is adopted as a catalyst for carrying out an ester exchange reaction to obtain a long spring cavoniflorac sodium/vinpocstine . The process production operation is, simple, avoids the high, 99.9% toxicity reagent, to obtain a, long spring cavonift, nitrogen oxide reaction, solution to, obtain a product, impurity at a time of acid. (by machine translation)