83356-60-9

Basic information

• Product Name: 3-<4-<2-hydroxy-3-(isopropylamino)propoxy>phenyl>propionic acid hydrochloride
• Synonyms: 3-<4-<2-hydroxy-3-(isopropylamino)propoxy>phenyl>propionic acid hydrochloride
• CAS NO: 83356-60-9
• Molecular Weight: 317.813
• Mol File: 83356-60-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 195-197°C
• CAS DataBase Reference: 3-<4-<2-hydroxy-3-(isopropylamino)propoxy>phenyl>propionic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-<4-<2-hydroxy-3-(isopropylamino)propoxy>phenyl>propionic acid hydrochloride(83356-60-9)
• EPA Substance Registry System: 3-<4-<2-hydroxy-3-(isopropylamino)propoxy>phenyl>propionic acid hydrochloride(83356-60-9)

Safety Data

• Hazardous Substances Data: 83356-60-9(Hazardous Substances Data)

Usage

Uses

The major metabolite of Esmolol (E668000) in humans.

Upstream product

• 81148-15-4 3-<4-<2-hydroxy-3-(isopropylamino)propoxy>phenyl>propionic acid 
• 81161-17-3 esmolol hydrochloride 
• 81147-94-6 methyl 3-<4-(2,3-epoxypropoxy)phenyl>propionate 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 501-97-3 4-hydroxyphenylpropionic acid 

Relevant articles and documents

Hitting a soft drug with a hard nucleophile: Preparation of esmolol's metabolite by treatment with bis(tributyltin) oxide

A facile method for the production of esmolol's metabolite in high purity is described. Bis(tributyltin) oxide is used to disrupt esmolol's ester linkage, and hydrolysis is completed by addition of water, which also allows the inorganic side products to be conveniently extracted into ether. Evaporation of the aqueous phase and trituration with ethyl acetate provides the carboxylic acid-amine internal salt as a white, free-flowing powder. Taylor & Francis Group, LLC.