83379-28-6

Usage

Uses

Used in Pharmaceutical Industry:
2'-deoxysangivamycin is used as an antibiotic agent for its potent antimicrobial activity against various bacterial strains, including those that are drug-resistant. Its unique sugar moiety and aminocyclitol core contribute to its effectiveness in treating infections and make it a promising candidate for further development as a pharmaceutical agent.
Used in Antibiotic Drug Discovery Research:
2'-deoxysangivamycin is used as a research compound for its structural features and biological activity, which make it an important asset in the field of antibiotic drug discovery. Its potential in treating drug-resistant bacterial infections highlights the need for further investigation and development of new antibiotics based on its properties.

InChI:InChI=1/C12H15N5O4/c13-10-9-5(11(14)20)2-17(12(9)16-4-15-10)8-1-6(19)7(3-18)21-8/h2,4,6-8,18-19H,1,3H2,(H2,14,20)(H2,13,15,16)

Upstream product

• 110089-46-8 4-amino-6-bromo-7-(2-deoxy-3,5-di-O-acetyl-β-D-erythro-pentofuranosyl)pyrrolo<2,3-d>-pyrimidine-5-carbonitrile 
• 110089-47-9 4-amino-7-(2-deoxy-3,5-di-O-acetyl-β-D-erythro-pentofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carbonitrile 
• 83379-26-4 6-bromo-2'-O-tosylsangivamycin 
• 83379-25-3 6-bromo-2'-O-tosyltoyocamycin 
• 83379-24-2 6-bromo-2',3'-O-(dibutylstannylene)sangivamycin 
• 83379-23-1 6-bromo-2',3'-O-(dibutylstannylene)toyocamycin 
• 85335-81-5 4-Amino-7-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 
• 166247-63-8 7-deaza-2'-deoxy-7-iodoadenosine 
• 83379-27-5 6,2'-S-cyclosangivamycin hydrobromide 
• 110089-49-1 4-amino-6-bromo-7-(2-deoxy-β-D-erythro-pentofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 15676-19-4 4-amino-5-cyano-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 110089-45-7 4-amino-6-bromo-7-(2-deoxy-β-D-erythro-pentofuranosyl)pyrrolo<2,3-d>-pyrimidine-5-carbonitrile 
• 110089-43-5 2-bromo-5-(ethoxymethyleneamino)pyrrole-3,4-dicarbonitrile 
• 98130-58-6 2-amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile 

Relevant academic research and scientific papers

Incorporation of 2'-deoxysangivamycin in DNA duplexes: The conversion of a pyrrolo[2,3-d]pyrimidine nitrile to a carboxamide upon oligonucleotide deprotection

Oligonucleotides containing 2'-deoxysangivamycin are described. The phosphoramidite of 2'-deoxytoyocamycin was prepared and used in solid-phase synthesis. Upon deprotection the pyrrolo[2,3-d]pyrimidine nitrile residues were converted to carboxamides. Acco

NUCLEIC ACID RELATED COMPOUNDS. 42. A GENERAL PROCEDURE FOR THE EFFICIENT DEOXYGENATION OF SECONDARY ALCOHOLS. REGIOSPECIFIC AND STEREOSELECTIVE CONVERSION OF RIBONUCLEOSIDES TO 2 prime -DEOXYNUCLEOSIDES.

Treatment of unhindered secondary alcohols with phenoxythiocarbonyl chloride (phenyl chlorothionocarbonate) in pyridine/dichloromethane, or in acetonitrile with 4-dimethylaminopyridine catalysis for hindered alcohols, gave clean conversion to their O-phenoxythiocarbonyl derivatives. Reductive deoxygenation of these phenyl thionocarbonate esters proceeded smoothly, using tri-n-butyltin hydride and a free radical initiator in warm toluene. Overall conversion yields ranged from 57 to 78% for the naturally occurring nucleosides, nucleoside antibiotics, and methyl beta -D-ribofuranoside.