166247-63-8 Usage
Description
7-DEAZA-7-IODO-2'-DEOXYADENOSINE is a nucleoside analog with a unique chemical structure, characterized by the replacement of the nitrogen atom at the 7th position with a carbon atom and the presence of an iodine atom at the 7th position. It is derived from adenosine, a nucleoside that plays a crucial role in cellular processes such as energy transfer and signal transduction. The modification of adenosine to form 7-DEAZA-7-IODO-2'-DEOXYADENOSINE endows it with distinct properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
7-DEAZA-7-IODO-2'-DEOXYADENOSINE is used as a therapeutic agent for the treatment of certain types of cancer. Its unique chemical structure allows it to be incorporated into DNA during replication, leading to the inhibition of DNA synthesis and ultimately causing cell death in cancerous cells. The compound's photophysical properties also enable it to be used in photodynamic therapy, where it can generate reactive oxygen species upon light activation, causing damage to cancer cells.
Used in Research and Development:
7-DEAZA-7-IODO-2'-DEOXYADENOSINE is utilized as a research tool in the study of nucleic acid biochemistry, molecular biology, and drug discovery. Its ability to be incorporated into DNA by primer extension using specific polymerases makes it a valuable probe for investigating DNA replication, repair, and mutagenesis. Additionally, its photophysical properties can be exploited in the development of novel imaging techniques and sensors for monitoring cellular processes and detecting specific molecular targets.
Used in Diagnostic Applications:
The unique properties of 7-DEAZA-7-IODO-2'-DEOXYADENOSINE also make it a potential candidate for use in diagnostic applications. Its ability to be incorporated into DNA and its photophysical properties can be harnessed to develop assays for detecting specific genetic mutations, monitoring disease progression, or assessing the efficacy of therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 166247-63-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,2,4 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 166247-63:
(8*1)+(7*6)+(6*6)+(5*2)+(4*4)+(3*7)+(2*6)+(1*3)=148
148 % 10 = 8
So 166247-63-8 is a valid CAS Registry Number.
166247-63-8Relevant articles and documents
The DNA-stabilising nucleoside 7-iodo-2′-deoxytubercidin: Its structure in the solid state and in solution
Seela, Frank,Zulauf, Matthias,Rosemeyer, Helmut,Reuter, Hans
, p. 2373 - 2376 (1996)
The crystal structure of 7-iodo-2′-deoxytubercidin 2 has been determined and was compared with those of 2′-deoxytubercidin 3 and 2′-deoxyadenosine 4. The bulky 7-iodo substituent lies 13.2 pm below and the nitrogen of the 6-amino group 5.5 pm above the 7-deazapurine plane. The puckering of compound 2 is 3′E while compound 3 shows a 2′T3′ sugar pucker. The conformation in aqueous solution, determined by 1H NMR spectroscopy, is only slightly different, showing a 2′E conformation. The glycosylic bond torsion angle is anti in all cases.
4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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Page/Page column 54; 55; 56, (2015/12/08)
Provided is 4'-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
Palladium-catalyzed cross coupling of 7-iodo-2'-deoxytubercidin with terminal alkynes
Seela, Frank,Zulauf, Matthias
, p. 726 - 730 (2007/10/03)
The 7-alkynyl-2'-deoxytubercidins (7-deaza-2'-deoxyadenosines) 7-17 have been prepared by the Pd(0)/Cu(I)-catalyzed cross coupling of 7-iodo-2'-deoxytubercidin (2d) with terminal alkynes. The coupling products include 17α-ethynyltestosterone and 17α-ethynylestradiol derivatives (16, 17).