83392-08-9Relevant academic research and scientific papers
Synthesis of a novel nitroimidazole-spermidine derivative as a tumor-targeted hypoxia-selective cytotoxin
Papadopoulou, Maria V.,Rosenzweig, Howard S.,Bloomer, William D.
, p. 1519 - 1522 (2004)
A four-step synthesis of (R,S)-N4-[3-(2-nitro-1-imidazolyl)-2- hydroxypropyl]-spermidine trihydrochloride (4) is described and the utilization of the polyamine active transport system for the uptake of this compound in cells is demonstrated. Thus, V79 cells pretreated with an inhibitor of spermidine biosynthesis, α-difluoromethylornithine (DFMO), are ca. 2-fold more sensitive to 4 under hypoxic conditions, compared to untreated cells. Similarly, radiosensitization of hypoxic V79 cells by 4 is improved in DFMO-pretreated cells.
N-benzylpolyamines as vectors of boron and fluorine for cancer therapy and imaging: Synthesis and biological evaluation
Martin,Possémé,Le Barbier,Carreaux,Carboni,Seiler,Moulinoux,Delcros
, p. 3653 - 3664 (2007/10/03)
Cancer cells have high-affinity polyamine uptake systems with a low stringency for structural features. Putrescine, spermidine, and spermine have, therefore, been considered as potential vectors for the selective accumulation in tumors of therapeutically
