83392-36-3

Upstream product

• 2314-48-9 (S,S)-dimethyl trithiocarbonate 
• 99-91-2 para-chloroacetophenone 
• 41467-26-9 1-(4-chlorophenyl)-3,3-bis(methylsulfanyl)-2-propen-1-one 

Downstream Products

• 116145-45-0 2-(Bis-methylsulfanyl-methylene)-1-(4-chloro-phenyl)-4-methyl-pent-4-en-1-one 
• 843640-86-8 ethyl 2-{[(E)-3-(4-chlorophenyl)-1-(methylsulfanyl)-3-oxo-1-propenyl]amino}acetate 
• 936691-53-1 methyl 2-{[(E)-3-(4-chlorophenyl)-1-(ethylsulfanyl)-3-oxo-1-propenyl]amino}acetate 
• 1038750-44-5 [3-(4-chlorophenyl)-5-(methylsulfanyl)-2-thienyl](phenyl)methanone 
• 1038750-49-0 1-[3-(4-chlorophenyl)-5-(methylsulfanyl)-2-thienyl]-1-ethanone 
• 1142124-65-9 5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-(4-chlorophenyl)-3,4-dihydropyrimidin-2(1H)-one 
• 1142124-59-1 5-methylmercaptothiocarbonyl-4-phenyl-6-(4-chloro-phenyl)-3,4-dihydropyrimidin-2(1H)-one 
• 1142124-63-7 5-methylmercaptothiocarbonyl-4-(4-methoxyphenyl)-6-(4-chlorophenyl)-3,4-dihydropyrimidin-2(1H)-one 
• 1142124-87-5 3-(4-chlorobenzoyl)-2H-chromene-2-thione 
• 5761-14-8 1-(4-chlorophenyl)-3-morpholino-3-thioxopropan-1-one 
• 1374329-15-3 3-(4-chlorophenyl)-5-morpholino-1-phenyl-1H-pyrazole 
• 1374329-16-4 3-(4-chlorophenyl)-1-(3-fluorophenyl)-5-(4-phenylpiperazino)-1H-pyrazole 
• 1415910-30-3 C₁₅H₉ClO₃S 
• 1415910-36-9 C₁₆H₁₁ClO₂S 

Relevant academic research and scientific papers

Applying green and highly efficient approach for a facile synthesis of new thiazoloquinoline, thiazolopyridine, and thiazolonaphthyridine derivatives

Abstract: An eco-friendly approach for the synthesis of new thiazoloquinolines, thiazolopyridines, and thiazolonaphthyridines scaffolds has been achieved using α-enolicdithioesters, cysteamine, arylglyoxal monohydrate, and cyclic 1,3-diketones (dimedone,

Access to Fully Substituted Thiazoles and 2,3-Dihydrothiazoles via Copper-Catalyzed [4 + 1] Heterocyclization of α-(N-Hydroxy/aryl)imino-β-oxodithioesters with α-Diazocarbonyls

An efficient chemoselective practical route to fully substituted thiazoles and 2,3-dihydrothiazoles has been devised by [4 + 1] heterocyclization of α-(N-hydroxy/aryl)imino-β-oxodithioesters with in situ generated Cu-carbenoids of diazocarbonyls. The α-(N-hydroxy/aryl)imino-β-oxodithioesters are readily accessible by the reaction of β-oxodithioesters with nitrous acid/nitrosoarenes. The overall transformation involves sequential N-O/C-N bonds cleavage followed by cascade C-N/C-S bonds formation in one-pot. This new strategy allows full control over the introduction of various sensitive functional groups at different positions of the thiazole ring, broadening the arsenal of synthetic methods to obtain such scaffolds.

Silica-ZnCl2: An efficient and reusable solid catalyst for one pot synthesis of 5-methyl mercaptothiocarbonyl-4-aryl-3- dihydropyrimidin-2(1H)-ones under solvent-free conditions

Synthetic application of Silica-ZnCl2, as an efficient and eco-friendly catalyst for the synthesis of a small library of dihydropyrimidinones is described in this report. The reaction involves a one pot, multicomponent reaction of β-oxodithioca

Facile route to highly functionalized 2H-chromene-2-thiones via ring annulations of β-oxodithioesters with phenols catalyzed by AlCl3 under solvent-free conditions

A facile synthesis of chromene-2-thiones by the Pechmann condensation of phenols and β-oxodithioesters catalyzed by AlCl3 under solvent-free condition has been reported. The best results were obtained in the case of substituted phenols such as

An efficient transesterification of β-oxodithioesters catalyzed by stannous chloride under solvent-free conditions

Transesterification of β-oxodithioesters catalyzed by stannous chloride under solvent-free condition has been reported for the first time. The short reaction time and good to excellent yields using inexpensive catalysts are attractive features of this synthetic protocol. Copyright

Highly regioselective one-pot, three-component synthesis of 1-aryl-3,4-substituted/annulated-5-(cycloamino)/(alkylamino)pyrazoles from β-oxodithioesters

An efficient, highly regioselective protocol for the synthesis of the title compounds is reported. The reaction involves a one-pot, three-component cyclocondensation of β-oxodithioester, amine, and hydrazine in ethanol at reflux in the presence of a catal

4-Dimethylamino pyridine-promoted one-pot three-component regioselective synthesis of highly functionalized 4 H -thiopyrans via heteroannulation of β-oxodithioesters

A highly convergent and regioselective heteroannulation protocol for the synthesis of hitherto unreported highly substituted 2-amino-4-(aryl/alkyl)-5- (aroyl/heteroaroyl)-3-(cyano/carboalkoxy)-6-methylthio-4H-thiopyran derivatives has been developed. This

Molecular docking and in vitro antileishmanial evaluation of chromene-2-thione analogues

Leishmaniases are an epidemic in various countries, and the parasite is developing resistance against available drugs. Thus, development of new drugs against Leishmania is an open area of investigation for synthetic organic chemists. To meet this challeng

Biginelli and Hantzsch-type reactions leading to highly functionalized dihydropyrimidinone, thiocoumarin, and pyridopyrimidinone frameworks via ring annulation with β-oxodithioesters

An efficient and highly convergent route to dihydropyrimidinones (DHPMs) and hitherto unreported dihydropyridopyrimidinones has been developed by one-pot, three-component cyclocondensation of aromatic aldehydes, β-oxodithioesters, and urea/6-amino-1,3-dim

Novel 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones: Synthesis and evaluation of their antioxidant activities

A facile, convenient and high yielding synthesis of a combinatorial library of 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones has been developed by the condensation of easily accessible β-oxodithioesters and salicylaldehyde/substituted 2-hydroxybenzal