83393-23-1

Basic information

• Product Name: 8-(Phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one hydrochloride
• Synonyms: 8-(Phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one hydrochloride;N-Benzyl nortropinone hydrochloride;8-Benzyl-8-azabicyclo[3.2.1]octan-3-one hydrochloride;N-benzyltropinone HCl;N-Benzyltropinone Hydrochloride;8-Azabicyclo[3.2.1]octan-3-one,8-(phenylmethyl)-,hydrochloride
• CAS NO: 83393-23-1
• Molecular Formula: C₁₄H₁₇NO*ClH
• Molecular Weight: 251.76
• EINECS: 1533716-785-6
• Mol File: 83393-23-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-(Phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(Phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one hydrochloride(83393-23-1)
• EPA Substance Registry System: 8-(Phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one hydrochloride(83393-23-1)

Safety Data

• Hazardous Substances Data: 83393-23-1(Hazardous Substances Data)

Usage

General Description

8-(Phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one hydrochloride is a chemical compound that belongs to the class of bicyclic organic compounds. It is commonly used in research and experimental studies as it has been found to have potential applications in the field of medicine and pharmacology. 8-(Phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one hydrochloride is known to exhibit behavioral effects on the central nervous system and has been studied for its potential use in the treatment of various neurological disorders. Its unique chemical structure and pharmacological properties make it an interesting candidate for further exploration and development in the field of pharmaceuticals.

InChI:InChI=1/C14H17NO.ClH/c16-14-8-12-6-7-13(9-14)15(12)10-11-4-2-1-3-5-11;/h1-5,12-13H,6-10H2;1H

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 542-05-2 acetonedicarboxylic acid 
• 3287-99-8 benzylamine hydrochloride 

Downstream Products

• 5632-84-8 nortropinone 
• 538-09-0 nortropine 
• 949902-02-7 trifluoro-methanesulfonic acid 8-benzyl-8-aza-bicyclo[3.2.1]oct-2-en-3-yl ester 
• 128200-17-9 3α-(aminomethyl)-3β-hydroxy-8-benzyl-8-azabicyclo<3.2.1>octane 
• 363140-16-3 N-(8-benzyl-8-azabicyclo[3.2.1]octan-3α-yl)-N'-(2-methoxy-5-methylphenyl)carbamate 
• 18717-73-2 (1R,3r,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-ol 
• 128200-43-1 3-cyano-3-hydroxy-8-benzyl-8-azabicyclo<3.2.1>octane 

Relevant articles and documents

Enhanced antibacterial activity of endo-nortropine substituted (C-7) fluoroquinolones against V. cholerae, S. aureus and B. subtilis

Introduction: Bacterial infections account for maximum deaths worldwide than for any other single cause. Methods: Here in, we report a convenient synthesis of new fluoroquinolone molecules substituted with endo-nortropine and its derivatives at C-7position. All the synthesized molecules, when screened for their antibacterial activity by agar diffusion method against Vibrio cholerae, Bacillus subtilis, Staphylococcus aureus and Escherichia coli were found to be active against the first three strains. The shortlisted compounds in the series, RG and RO, were further evaluated to determine their MIC values by micro-dilution broth assay. Result & Conclusion: Compound RG was ten times more effective in case of S. aureus (15.0 nM), two times in case of V. cholerae (3.7 nM) and the same as that of standard drug Levofloxacin in case of Bacillus subtilis (7.8 nM). Compound RO also displayed an impressive MIC value (62.5 nM) in case of S. aureus as compared to control (125 nM). The results have been supported by in-silico docking studies, where increased hydrogen bonding interactions in case of RG as compared to standard drug levofloxacin with DNA gyrase (2XCT) of S. aureus resulted in decreased energy of the former.