538-09-0Relevant articles and documents
Nortropine alcohol salting-out preparation method
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Paragraph 0032; 0034-0036; 0038-0040; 0042-0044; 0046-0047, (2020/07/21)
The invention provides a nortropine alcohol salting-out preparation method, which comprises the following steps: by taking N-ethoxycarbonyl methyltropone as a raw material, carrying out Raney nickel catalytic hydrogenation, hydrolysis, salting-out and refining to finally obtain nortropine alcohol with the purity of more than 99%. The method has the following advantages: 1, the catalytic hydrogenation temperature of Raney nickel is relatively low (20-100 DEG C), and the pressure is 0.5-1MPa; 2, the tedious operation of extracting for 7-10 times by using chloroform is omitted, the use of a solvent is saved, and the pollution is reduced; and 3, the product quality is greatly improved, and the crude product can reach 98% or above.
A METHOD FOR THE N-DEMETHYLATION OF N-METHYL HETEROCYCLES
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, (2011/04/19)
The present invention provides methods of N-demethylating, N-methylated heterocycles and N-methyl, N-oxide heterocycles using a transition metal with an oxidation state of zero, ferrocene or substituted derivatives thereof, or Cr 3+ .N-demethylated heterocycles prepared by the methods of the present invention are also provided.
2,6-Disubstituted piperiddines as modulators
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Page/Page column 22, (2010/11/28)
The present invention is further directed to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R16, R17, R18, R19, R20, R21 and R22 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.