83396-77-4Relevant academic research and scientific papers
A chiral 1,2-bisphospholane ligand with a novel structural motif: Applications in highly enantioselective Rh-catalyzed hydrogenations
Tang, Wenjun,Zhang, Xumu
, p. 1612 - 1614 (2007/10/03)
TangPhos (1) is a highly efficient and practical ligand for asymmetric hydrogenations. High enantioselectivities and turnover numbers were observed in the Rh-catalyzed hydrogenation of α-(acylamino) acrylic acids and α-arylenamides.
UNUSUAL AMINO ACIDS. IV. ASYMMETRIC SYNTHESIS OF THIENYLALANINES
Doebler, Christian,Kreuzfeld, H.-J.,Krause, H. W.,Michalik, M.
, p. 1833 - 1842 (2007/10/02)
(Z)-2-N-Acylamino-3-thienyl-acrylic acids and thei esters were prepared by known procedures and hydrogenated to the corresponding optically active 2-N-acetyl(or benzoyl)-3-(2- or 3-thienyl)-alanines with optically yields up to 90percent using the rhodium complexes of 'PROPRAPHOS" 6a,b and O,N-bis(diphenylphosphino)-2-exo-hydroxy,3-endo-methylamino-norbornane 6c as chiral catalysts.Recrystallization and deacylation of the obtained amino acid derivatives yields the optically pure hydrochlorides of the thienylalanines as the free amino acids.
