83407-53-8Relevant academic research and scientific papers
1-Phenyl-6,7-disubstituted-2-(3-disubstituted-aminopropyl)-1,2,3,4-tetrahydroisoquinolines as Possible Antitubercular Agents
Kumar, P.,Dhawan, K. N.,Kishor, K.,Bhargaval, K. P.,Satsangi, R. K.
, p. 677 - 679 (2007/10/02)
The condensation of 3,4-disubstituted phenylethylamine and benzaldehyde furnished 1-phenyl-6,7-disubstituted-1,2,3,4-tetrahydroisoquinolines 1 which on reaction with 1,3-dibromopropane gave 1-phenyl-6,7-disubstituted-2-(3-bromopropyl)-1,2,3,4-tetrahydroisoquinolines 2.The reaction of 2 with different secondary amines resulted in the synthesis of 3.The compounds 3 were screened for their in vitro antitubercular activity against Mycobacterium smegmatis, and some of them have been found to be total inhibitors of M.Smegmatis.
