83407-57-2

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 100-52-7 benzaldehyde 
• 4118-36-9 6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 110-91-8 morpholine 
• 83407-60-7 1-Phenyl-2-(3-bromopropyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

1-Phenyl-6,7-disubstituted-2-(3-disubstituted-aminopropyl)-1,2,3,4-tetrahydroisoquinolines as Possible Antitubercular Agents

The condensation of 3,4-disubstituted phenylethylamine and benzaldehyde furnished 1-phenyl-6,7-disubstituted-1,2,3,4-tetrahydroisoquinolines 1 which on reaction with 1,3-dibromopropane gave 1-phenyl-6,7-disubstituted-2-(3-bromopropyl)-1,2,3,4-tetrahydroisoquinolines 2.The reaction of 2 with different secondary amines resulted in the synthesis of 3.The compounds 3 were screened for their in vitro antitubercular activity against Mycobacterium smegmatis, and some of them have been found to be total inhibitors of M.Smegmatis.