83410-37-1Relevant articles and documents
Compounds for treating spinal muscular atrophy
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Page/Page column 398, (2017/05/02)
Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.
Synthesis of novel 5,6-substituted furo[2,3-d]pyrimidines via Pd-catalyzed cyclization of alkynylpyrimidinols with aryl iodides
Liu, Zhende,Li, Dewen,Li, Shukun,Bai, Donglu,He, Xuchang,Hu, Youhong
, p. 1931 - 1936 (2007/10/03)
A flexible method for the synthesis of 5,6-disubstituted furo[2,3-d]pyrimidine derivatives is described. The key step is a palladium-catalyzed arylative cyclization of alkynylpyrimidinols with various aryl iodides, which gave the title compounds in 36-75% yield.
Substituted pyridopyrimidines and antihypertensives
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, (2008/06/13)
This invention relates to substituted pyridopyrimidinones of general formula (I): STR1 wherein R1 and R2 are independently H, lower alkyl containing 1 to 6 carbon atoms, hydroxyalkyl containing 1 to 6 carbon atoms, formyl, carbonylalkyl containing 1 to 6 carbon atoms, carboxy, or carboxyalkyl containing 1 to 6 carbon atoms; R3 and R4 are independently H, lower alkyl containing 1 to 6 carbon atoms, hydroxy; R3a and R4a are H, and when taken together with R3 and R4 respectively comprise a carbonyl; with the proviso that at least one of the groups R1 and R2 must be hydroxyalkyl, formyl, carbonylalkyl containing 1 to 6 carbon atoms, carboxy, or carboxyalkyl containing 1 to 6 carbon atoms; or R3 and R4 must be hydroxy or taken together with R3a and R4a respectively must comprise a carbonyl; n is 0 to 3; Ar1 is STR2 wherein W is H, lower alkyl containing 1 to 6 carbon atoms, halogen, hydroxy, or lower alkoxy containing 1 to 6 carbon atoms; Ar2 is STR3 wherein X is CO2 H, CN, or STR4 wherein R5 is H, CH3, tert-butyl, tri-n-butylstannyl, or triphenylmethyl; and the pharmaceutically acceptable salts thereofuseful for treating hypertension and congestive heart failure, to pharmaceutical compositions, and to methods for production thereof.