83416-89-1

Upstream product

• 83416-88-0 C₄₁H₃₄Cl₃N₅O₁₃P₂ 
• 50408-20-3 2',3'-di-O-benzoyluridine 
• 130-16-5 5-Chloro-8-hydroxyquinoline 
• 83416-85-7 Phosphoric acid bis-(5-chloro-quinolin-8-yl) ester (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 
• 83416-84-6 bis(5-chloro-8-quinolyl) phosphate 

Relevant academic research and scientific papers

Synthesis of Bis(5-chloro-8-quinolyl) Nucleoside 5'-Phosphates in Oligoribonucleotide Synthesis by the Phosphotriester Approach

A new phosphorylating agent, bis(5-chloro-8-quinolyl) phosphate was found to be a useful agent for the phosphorylation of the 5'-hydroxyl group of unprotected nucleosides.This agent smoothly reacts with 3',5',-unprotected nucleosides in the presence of 8-quinolinesulfonyl tetrazolide (QS-t) to give the corresponding bis(5-chloro-8-quinolyl) nucleoside 5'-phosphates in good yields without 3'-mono- and 3',5'-diphosphorylated products.They are key intermediates for the synthesis of oligoribonucleotides bearing 5'-terminal phosphate.Zinc chloride can be used as an effective and mild agent for removal of 5-chloro-8-quinolyl group.