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50408-20-3

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50408-20-3 Usage

General Description

2',3'-DI-O-BENZOYLURIDINE is a chemical compound with the molecular formula C20H18N2O5. It is a derivative of uridine, which is a nucleoside found in RNA and plays a role in cellular metabolism. 2',3'-DI-O-BENZOYLURIDINE is often used as a substrate for enzyme assays to study the activity of enzymes involved in nucleoside metabolism. It can also be used in the synthesis of nucleoside analogs, which have potential therapeutic applications in antiviral and anticancer treatments. The compound is a white to off-white powder and should be stored in a cool, dry place protected from moisture and light.

Check Digit Verification of cas no

The CAS Registry Mumber 50408-20-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,4,0 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 50408-20:
(7*5)+(6*0)+(5*4)+(4*0)+(3*8)+(2*2)+(1*0)=83
83 % 10 = 3
So 50408-20-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H20N2O8/c26-13-16-18(32-21(28)14-7-3-1-4-8-14)19(33-22(29)15-9-5-2-6-10-15)20(31-16)25-12-11-17(27)24-23(25)30/h1-12,16,18-20,26H,13H2,(H,24,27,30)/t16-,18-,19-,20-/m1/s1

50408-20-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2',3'-di-O-benzoyl-uridine

1.2 Other means of identification

Product number -
Other names 2,'3'-di-O-benzoyluridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50408-20-3 SDS

50408-20-3Relevant articles and documents

Bismethylene triphosphate nucleotides of uridine 4-phosphate analogues: A new class of anionic pyrimidine nucleotide analogues

Taylor, Scott D.,Mirzaei, Farzad,Bearne, Stephen L.

, p. 1403 - 1412 (2008/09/17)

(Chemical Equation Presented) Cytidine-5′-triphosphate synthase (CTPS) catalyzes the formation of cytidine triphosphate (CTP) from glutamine, uridine 5′-triphosphate (UTP), and adenosine 5′-triphosphate (ATP). This reaction proceeds via formation of the high-energy intermediate UTP-4-phosphate (UTP-4-P). Stable analogues of UTP-4-P may be potent inhibitors of CTPS and useful as lead structures for the development of anticancer and antiviral agents. Several bismethylene triphosphate (BMT) nucleotides of uridine 4-phosphate (U-4-P) analogues have been prepared. A key step was the selective methanolysis, with the aid of a tin catalyst, of the 5′ ester moiety of 2′,3′,5′-tri-O-acetyl or tri-O-benzoyl U-4-P analogues. We believe this represents the first general approach to the selective cleavage of 5′ benzoyl esters in benzoylated nucleosides. Mitsunobu coupling of these 5′-deprotected U-4-P analogues to an unsymmetrical, protected BMT bearing a free phosphonic acid moiety at one of the terminal positions gave fully protected BMT-U-4-P analogues. Global deprotection of these species was achieved using TMSBr followed by treatment with NH4OH-MeOH or NH 4OH-pyridine. The resulting BMT nucleotides represent a new class of anionic pyrimidine nucleotide analogues.

Durenesulfonic Acid Derivatives as New Condensing Reagents in the Nucleotide Synthesis Following the Triester Method

Losse, Guenter,Stang, Norbert

, p. 19 - 24 (2007/10/02)

As shown by the synthesis of a series of ribonucleotide blocks durenesulfonyl chloride/1-methylimidazole and 1-(3-durenylsulfonyloxy)-6-nitrobenzotriazole (15) are adventageous alternative condensing reagents for the triester method.Hereby the 2'-OH function of the ribose is protected by the 4-methoxybenzyl group, which can be removed suitably by dry TFA/anisole instead of trityl tetrafluoroborate.

Synthesis of 2',3'-Differentiated Ribonucleosides via Glycosylation. Reactions with 2-O-Me or 2-O-TBDMS Ribofuranose Derivatives. 1. Pyrimidine Series

Chavis, C.,Dumont, F.,Wightman, R. H.,Ziegler, J. C.,Imbach, J. L.

, p. 202 - 206 (2007/10/02)

The synthesis of 2',3' asymmetrically substituted pyrimidine ribonucleosides in 70-95percent yields by using modified Vorbruggen conditions with "nonparticipating" 2-O-CH3 and 2-O-TBDMS ribofuranoses is described.Such compounds are useful synthons for oligoribonucleotide synthesis, including incorporation of "rare" bases.New and practically useful conditions for placement (using 1,2,4-triazole) and removal (KF/crown ether) of the tert-butyldimethylsilyl (TBDMS) protecting group are also reported.

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