83416-90-4

Upstream product

• 83416-87-9 Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester bis-(5-chloro-quinolin-8-yl) ester 
• 81366-72-5 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate 
• 60324-96-1 2'-O-(tetrahydropyranyl)-N²-benzoylguanosine 
• 130-16-5 5-Chloro-8-hydroxyquinoline 
• 83416-84-6 bis(5-chloro-8-quinolyl) phosphate 

Downstream Products

• 83416-91-5 C₄₉H₃₉Cl₃N₈O₁₃P₂ 

Relevant academic research and scientific papers

Synthesis of Bis(5-chloro-8-quinolyl) Nucleoside 5'-Phosphates in Oligoribonucleotide Synthesis by the Phosphotriester Approach

A new phosphorylating agent, bis(5-chloro-8-quinolyl) phosphate was found to be a useful agent for the phosphorylation of the 5'-hydroxyl group of unprotected nucleosides.This agent smoothly reacts with 3',5',-unprotected nucleosides in the presence of 8-quinolinesulfonyl tetrazolide (QS-t) to give the corresponding bis(5-chloro-8-quinolyl) nucleoside 5'-phosphates in good yields without 3'-mono- and 3',5'-diphosphorylated products.They are key intermediates for the synthesis of oligoribonucleotides bearing 5'-terminal phosphate.Zinc chloride can be used as an effective and mild agent for removal of 5-chloro-8-quinolyl group.