83422-46-2

Usage

Type of Compound

Anthelmintic or anti-parasitic medication

Usage

Treats a variety of parasitic infections in humans and animals

Specific Infections Treated

Roundworm, hookworm, and tapeworm infestations

Mechanism of Action

Interferes with the metabolism of the parasites, leading to their eventual death

Available Forms

Tablets and suspensions

Administration

Typically taken orally

Recognition

Considered an essential medicine by the World Health Organization

Factors for Recognition

Effectiveness in treating parasitic infections and relatively low cost

Upstream product

• 857439-68-0 N-(3-chloro-phenyl)-o-phenylenediamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 74002-27-0 N-(3-chlorophenyl)-2-nitroaniline 
• 1493-27-2 ortho-nitrofluorobenzene 
• 57-13-6 urea 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 83421-96-9 8-[3-(3-chlorophenyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid methyl ester 
• 83421-95-8 7-[3-(3-Chlorophenyl)-2-oxo-benzimidazolin-1-yl]-enanthic ethyl ester 
• 860031-59-0 3-(3-chloro-phenyl)-5-[hydroxy-(4-iodo-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-1,3-dihydro-benzoimidazol-2-one 
• 860031-76-1 3-(3-chloro-phenyl)-5-(4-iodo-benzoyl)-1-methyl-1,3-dihydro-benzoimidazol-2-one 
• 860031-75-0 5-(4-chloro-benzoyl)-3-(3-chloro-phenyl)-1-methyl-1,3-dihydro-benzoimidazol-2-one 
• 860031-57-8 5-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-3-methyl-1,3-dihydro-benzoimidazol-2-one 
• 860031-56-7 1-(3-chlorophenyl)-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 

Relevant academic research and scientific papers

Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays role in several disorders such as obesity, stress, depression and anxiety. The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified.

Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: Synthesis and activity

A series of analogs of tipifarnib (1) has been synthesized as inhibitors of FTase by substituting the benzimidazolones and indoles for the 2-quinolone of tipifarnib. The novel benzimidazolones are potent and selective FTase inhibitors (FTIs) with IC50 values of the best compounds close to that of tipifarnib. The current series demonstrate good cellular activity as measured in their inhibiting the Ras processing in NIH-3T3 cells, with compounds 2c and 2f displaying EC50 values of 18 and 22 nM, respectively.