83431-80-5

Usage

Uses

Used in Pharmaceutical Applications:
(6E)-6-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-ylidene]cyclohexa-2,4-dien-1-one is used as a key intermediate in the synthesis of new drugs, leveraging its cyclohexa-2,4-dien-1-one moiety to create compounds with unique therapeutic properties.
Used in Agrochemical Applications:
(6E)-6-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-ylidene]cyclohexa-2,4-dien-1-one is utilized as a building block in the development of novel agrochemicals, contributing to the creation of more effective and environmentally friendly products for the agricultural industry.
Used in Materials Science:
(6E)-6-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-ylidene]cyclohexa-2,4-dien-1-one is employed as a component in the design and synthesis of advanced materials with specific properties, such as improved stability or enhanced performance in various applications.
Used in Biological Research:
As a fluorescent label, (6E)-6-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-ylidene]cyclohexa-2,4-dien-1-one is used in biological research to study various processes in living cells, thanks to the nitrophenyl group that provides photophysical properties.
Overall, (6E)-6-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-ylidene]cyclohexa-2,4-dien-1-one demonstrates a wide range of applications across different industries, showcasing its versatility and potential for further development and innovation.

Upstream product

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Relevant academic research and scientific papers

Complex, its preparation method, fluorinion sensor and method for detecting fluorinion

The invention provides a complex as shown in a chemical formula 1 in the specification, a preparation method of the complex, a fluorine ion sensor and a method for detecting a fluorine ion. In the chemical formula 1, m is an integer from 0 to 5, n is an integer from 0 to 4, R1, R2 and R3 are independently selected from a group composed of deuterium, tritium, halogen, a cyano group, an amino group, nitryl, hydroxyl, carboxyl, substituted or unsubstituted C2-C30 ether groups, substituted or unsubstituted C2-C30 ester groups, substituted or unsubstituted C1-C30 alkyls, substituted or unsubstituted C2-C30 alkenyls, substituted or unsubstituted C2-C30 alkynyls, substituted or unsubstituted C3-C30 cycloalkyls, substituted or unsubstituted C1-C30 alkoxyl groups, substituted or unsubstituted C3-C30 cycloalkoxyls, substituted or unsubstituted C5-C30 aryls, substituted or unsubstituted C5-C30 aryloxys and substituted or unsubstituted C3-C30 heteroaryls.

Compound, preparation method thereof, fluorinion sensor and method for detecting fluorinion

The invention provides a compound disclosed as chemical formula 1 and a preparation method thereof, a fluoride ion sensor and a fluorine ion detection method. In the chemical formula 1, m is a whole number ranging from 0 to 5, n is a whole number ranging from 0 to 4, and R1 and R2 are respectively independently selected from deuterium, tritium, halogen, cyano gorup, amino group, nitro group, hydroxy group, carboxyl group, substituted or unsubstituted C2-C30 ether group, substituted or unsubstituted C2-C30 ester group, substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C2-C30 alkenyl group, substituted or unsubstituted C2-C30 alkynyl group, substituted or unsubstituted C3-C30 cycloalkyl group, substituted or unsubstituted C1-C30 alkoxy group, substituted or unsubstituted C3-C30 cycloalkoxy group, substituted or unsubstituted C5-C30 aryl group, substituted or unsubstituted C5-C30 aryloxy group and substituted or unsubstituted C3-C30 heteroaryl group.

Synthesis and Biological Evaluation of Some Heterocyclic Compounds from Salicylic Acid Hydrazide

Different heterocyclic compounds were prepared starting from 2-hydroxy benzohydrazide; for example, cyclization of hydrazide hydrazone 3 derived from 2-hydroxybenzohydrazide 2 with acetic anhydride or concentrated sulfuric acid gave 1,3,4-oxadiazole derivatives 4–5. On the other hand, direct cyclization of 2-hydroxy benzohydrazide 2 with one carbon cyclizing agent gave a new derivative of 1,3,4-oxadiazole 7, 8, 9, 10, 11. Heating of hydrazide hydrazone 3 with thioglycolic acid in pyridine gave thiazolidinone 12. When 2-hydroxy benzohydrazide 2 reacted with aliphatic carboxylic acids such as formic acid or acetic acid, it gave the corresponding N-formyl or N-acetyl derivatives 6. Subsequent cyclization of 6 using phosphorous pentasulphide in pyridine gave 1,3,4-thiadiazoles 13. Cyclization of 2-hydroxy benzohydrazide with ethyl acetoacetate gives pyrazolone derivative 14. Finally, when an ethanolic solution of acid hydrazide 2 was treated with ammonium thiocyanate in 35% HCl, it gave the thiosemicarbazide 15. Subsequent treatment of 15 with concentrated sulfuric acid or 10% sodium hydroxide gave 5-amino-1,3,4-thiadiazole 16 and 1,2,4-triazole 17, respectively. The structures of all newly isolated compounds were confirmed using1H NMR, IR spectra, and elemental analyses. The antimicrobial activities for all isolated compounds were examined against different microorganisms.

Studies on Thioamides and Their Derivatives,VI. New Synthesis of 5-Membered Heterocyclic Compounds

Simple N-monosubstituted thioamides react with acid hydrazides to form 1,2,4-triazole derivatives.N,N-Disubstituted thioamides alkylated with methyl iodide readily yield with acid hydrazides 1,3,4-oxadiazoles.