83434-64-4

Upstream product

• 89495-63-6 Dimethyl-thiocarbamic acid O-[(2R,6R,11R)-6,11-dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl] ester 
• 7488-49-5 (-)-pentazocine 
• 89495-63-6 Dimethyl-thiocarbamic acid O-[(2R,6R,11R)-6,11-dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl] ester 
• 359-83-1 pentazocin 
• 359-83-1 (6R,11R)-6,11-Dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol 
• 98-88-4 benzoyl chloride 
• 89495-73-8 Dimethyl-thiocarbamic acid S-[(2R,6R,11R)-6,11-dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl] ester 
• 89495-73-8 Dimethyl-thiocarbamic acid S-[(2R,6R,11R)-6,11-dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl] ester 

Relevant academic research and scientific papers

SYNTHESIS OF NOVEL POTENT NON-NARCOTIC LESS SIDE-EFFECT ANALGESICS: 2'-ACYLTHIO- AND 2'-ALKYLTHIO-6,7-BENZOMORPHANS

2'-Acylthio- and 2'-alkylthio-6,7-benzomorphans were synthesized from 2'-hydroxy-6,7-benzomorphans in 4 steps.Newman-Kwart rearrangement of 2'-N,N-dimethylthiocarbamoyloxy derivatives proceeded in almost quantitative yields to give rearranged 2'-N,N-dimethylcarbamoylthio derivatives.Reductive cleavage and successive acylation afforded title compounds.These novel sulfur-containing benzomorphans showed strong analgesic activities with less side effects.