83451-93-8Relevant academic research and scientific papers
Pyrimidinyl ureido penicillins
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, (2008/06/13)
Compounds of the formula STR1 wherein A is phenyl, 4-hydroxy-phenyl, 2-thienyl or 3,4-dihydroxy-phenyl; and R is STR2 where R1 and R2, which may be identical to or different from each other, are each methylmercapto or amino; Z' is oxygen, sulfur or =NR3 ; R3 is hydrogen, alkyl of 1 to 3 carbon atoms or hydroxy-(alkyl of 1 to 3 carbon atoms); R4 is hydrogen, hydroxyl, hydroxymethyl or methyl; n is 2, 3 or 4; Y is --SO2 NH--, --SO-- or --SO2 --; Z is straight or branched alkylene of 1 to 3 carbon atoms; X is hydroxyl, aminocarbonyl, aminosulfonyl, formylamino, acetylamino, amino, methylsulfinyl, methylsulfonyl or STR3 or --Y--Z--X is STR4 and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as the salts are useful as antibiotics.
