83458-71-3

Upstream product

• 75-44-5 phosgene 
• 75715-72-9 (2α,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine 
• 75715-68-3 Phenyl-((2S,7R,11bS)-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-amine 
• 75715-73-0 (2β,7α,11bα)-1,3,4,6,7,11b-hexahydro-N,7-diphenyl-2H-benzoquinolizin-2-amine 

Downstream Products

• 87680-33-9 3-Methyl-1-phenyl-1-((2R,7S,11bS)-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-urea 
• 87680-27-1 2α-(2-chloroethyl)-1,6,7,11bα-tetrahydro-3,7α-diphenyl-2H-pyrimido<6,1-a>isoquinolin-4(3H)-one 
• 87680-28-2 2β-(2-chloroethyl)-1,6,7,11bα-tetrahydro-3,7β-diphenyl-2H-pyrimido<6,1-a>isoquinolin-4(3H)-one 
• 87680-32-8 3-Methyl-1-phenyl-1-((2S,7S,11bS)-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-urea 

Relevant academic research and scientific papers

A NOVEL BENZOQUINOLIZIDINE REARRANGEMENT INVOLVING INTRAMOLECULAR CARBAMYL-CHLORIDE-INDUCED CLEAVAGE OF A TERTIARY AMINE

The free base of benzoquinolizidine 3 undergoes a facile rearrangement to pyrimidoisoquinoline 4, the structure of which was confirmed by x-ray crystallography.The regiospecificity of this novel rearrangement is governed by stereoelectronic factors.

Dealkylation of a Tertiary Amine Group by an Intramolecular Carbamyl Chloride Functionality

Compounds containing a 4-anilinopiperidine moiety react with phosgene to afford carbamyl chloride hydrochloride derivatives, which rearrange in the presence of nonnucleophilic amine bases.The rearrangement entails intramolecular acylation by the carbamyl