83463-01-8Relevant articles and documents
Regioselective synthesis of enones via a titanium-promoted coupling of unsymmetrical alkynes with Weinreb amides
Silwal, Sajan,Rahaim, Ronald J.
, p. 8469 - 8476 (2014)
A modular titanium-promoted coupling of unsymmetrical internal alkynes with Weinreb amides is described. The coupling reaction takes place at room temperature and affords E-trisubstituted enones in moderate to good yields with high levels of regioselectivity. The system shows moderate chemoselectivity.