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83463-80-3

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83463-80-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 83463-80-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,4,6 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83463-80:
(7*8)+(6*3)+(5*4)+(4*6)+(3*3)+(2*8)+(1*0)=143
143 % 10 = 3
So 83463-80-3 is a valid CAS Registry Number.

83463-80-3Downstream Products

83463-80-3Relevant articles and documents

NiH-Catalyzed Hydroamination/Cyclization Cascade: Rapid Access to Quinolines

Chen, Qian,Gao, Yang,Hu, Xiao-Qiang,Huo, Yanping,Li, Xianwei,Yang, Simin

, p. 7772 - 7779 (2021/06/30)

Despite the significant success of metal-H-catalyzed hydroamination methodologies, considerable limitations still exist in the selective hydroamination of alkynes, especially for terminal alkynes. Herein, we develop a highly efficient NiH catalytic system that activates readily available alkynes for a cascade hydroamination/cyclization reaction with anthranils. This mild, operationally simple protocol is amenable to a wide array of alkynes including terminal and internal, aryl and alkyl, electron-deficient and electron-rich ones, delivering structurally diverse quinolines in useful to excellent yields (>80 examples, up to 93% yield). The utility of this procedure is exhibited in the late-stage functionalization of several natural products and in the concise synthesis of an antitumor molecule graveolinine and a triplex DNA intercalator. Preliminary mechanistic experiments suggest an alkenylnickel-mediated alkyne hydroamination and an intramolecular cyclization/aromatization of putative enamine intermediates.

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